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Nanotoxicology

Materials, Methodologies, and Assessments

  • Book
  • © 2014

Overview

Editors:
  1. Nelson Durán

    1. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, Brazil

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  2. Silvia S. Guterres

    1. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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    You can also search for this editor in PubMed   Google Scholar

  3. Oswaldo L. Alves

    1. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, Brazil

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  • Provides an introduction to nanostructures actually in use
  • Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays
  • Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity
  • Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology
  • Includes supplementary material: sn.pub/extras

Part of the book series: Nanomedicine and Nanotoxicology (NANOMED)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Nanomaterials

    • Oswaldo L. Alves, Ana Carolina Mazarin de Moraes, Mateus Batista Simões, Leandro Carneiro Fonseca, Rafaella Oliveira do Nascimento, Raphael Dias Holtz et al.
    Pages 1-29

  3. Concepts and Methodology of Interaction of Carbon Nanostructures with Cellular Systems

    • Alexandre L. R. de Oliveira, Helder J. Ceragioli, Kyl Assaf
    Pages 31-55

  4. Nanostability

    • Ana Cauerhff, Yanina N. Martinez, German A. Islan, Guillermo R. Castro
    Pages 57-95

  5. Pharmacokinetics and Pharmacodynamics of Nanomaterials

    • Priscyla D. Marcato
    Pages 97-110

  6. In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines

    • Patricia S. Melo, Priscyla D. Marcato, Daniele R. de Araújo, Nelson Durán
    Pages 111-123

  7. Carbon Nanotubes: From Synthesis to Genotoxicity

    • Diego Stéfani T. Martinez, Leonardo P. Franchi, Camila M. Freria, Odair P. Ferreira, Antonio G. Souza Filho, Oswaldo L. Alves et al.
    Pages 125-152

  8. From Combinatorial Display Techniques to Microarray Technology: New Approaches to the Development and Toxicological Profiling of Targeted Nanomedicines

    • Giselle Z. Justo, Eloah R. Suarez, Carina Melo, Marcelo A. Lima, Helena B. Nader, Maria Aparecida S. Pinhal
    Pages 153-175

  9. Genetic Studies on the Effects of Nanomaterials

    • Renata de Lima, Leonardo Fernandes Fraceto
    Pages 177-199

  10. Cellular Mechanisms in Nanomaterial Internalization, Intracellular Trafficking, and Toxicity

    • Marcelo Bispo de Jesus, Yvonne L. Kapila
    Pages 201-227

  11. Cytotoxicity and Genotoxicity of Solid Lipid Nanoparticles

    • Priscyla D. Marcato, Nelson Durán
    Pages 229-244

  12. Cytotoxicity and Genotoxicity of Biogenically Synthesized Silver Nanoparticles

    • Nelson Durán, Amedea B. Seabra, Renata de Lima
    Pages 245-263

  13. Cytotoxicity and Genotoxicity of Iron Oxides Nanoparticles

    • Amedea B. Seabra, Paula S. Haddad
    Pages 265-279

  14. Poloxamers as Drug-Delivery Systems: Physicochemical, Pharmaceutical, and Toxicological Aspects

    • Daniele R. de Araújo, Alisson Oshiro, Deyse Cardoso da Silva, Alessandra Cristina Santos Akkari, Joyce Cristine de Mello, Tiago Rodrigues
    Pages 281-298

  15. Polymeric Nanoparticles: In Vivo Toxicological Evaluation, Cardiotoxicity, and Hepatotoxicity

    • Solange C. Garcia, Silvia S. Guterres, Guilherme B. Bubols, Rachel P. Bulcão, Mariele F. Charão, Adriana R. Pohlmann
    Pages 299-324

  16. Cyto-, Geno-, and Ecotoxicity of Copper Nanoparticles

    • Mahendra Rai, Avinash Ingle, Indarchand Gupta, Swapnil Gaikwad, Aniket Gade, Olga Rubilar et al.
    Pages 325-345

  17. Assessing the Erythrocyte Toxicity of Nanomaterials: From Current Methods to Biomolecular Surface Chemistry Interactions

    • Luis A. Visani de Luna, Diego Stéfani T. Martinez, Oswaldo L. Alves
    Pages 347-361

  18. Toxicity of Nanomaterials to Microorganisms: Mechanisms, Methods, and New Perspectives

    • Andreia Fonseca de Faria, Ana Carolina Mazarin de Moraes, Oswaldo L. Alves
    Pages 363-405

  19. Back Matter

    Pages 407-411
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Keywords

About this book

This book takes a systematic approach to nanotoxicology and the developing risk factors associated with  nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures.

  • Provides an introduction to nanostructures actually in use
  • Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays
  • Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity
  • Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology

Editors and Affiliations

  • Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, Brazil

    Nelson Durán, Oswaldo L. Alves

  • Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Silvia S. Guterres

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