Vascular Mechanisms in CNS Trauma

1. Front Matter

   Pages i-xx

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2. Molecular Mechanisms

   1. Front Matter

      Pages 1-1

      PDF

   2. CNS Barriers in Neurotrauma

      • Adam Chodobski, Brian J. Zink, Joanna Szmydynger-Chodobska

      Pages 3-28

   3. Mechanisms of Cerebral Edema Leading to Early Seizures After Traumatic Brain Injury

      • Philip H. Iffland II, Gerald A. Grant, Damir Janigro

      Pages 29-45

   4. Human Cerebral Blood Flow and Traumatic Brain Injury

      • David A. Hovda, Thomas C. Glenn

      Pages 47-54

   5. Gliovascular Targets in Traumatic CNS Injury

      • Arjun Khanna, Brian P. Walcott, Kristopher T. Kahle, Volodymyr Gerzanich, J. Marc Simard

      Pages 55-73

   6. Neurovascular Responses to Traumatic Brain Injury

      • Josephine Lok, Ken Arai, Shu-zhen Guo, Wendy Leung, Takakuni Maki, Deepti Navaratna et al.

      Pages 75-103

   7. The Effects of Intravascular Coagulation and Microthrombosis on Cerebral Perfusion After Brain Trauma

      • Monisha A. Kumar, Douglas H. Smith, Sherman C. Stein

      Pages 105-124

   8. Barriers to Drug Delivery for Brain Trauma

      • F. Anthony Willyerd, Philip E. Empey, Patrick M. Kochanek, Robert S. B. Clark

      Pages 125-140

   9. Angiogenesis and Functional Recovery After Traumatic Brain Injury

      • Yanlu Zhang, Ye Xiong, Asim Mahmood, Zheng Gang Zhang, Michael Chopp

      Pages 141-156

   10. Vascular Mechanisms in Spinal Cord Injury

       • Theo Hagg

       Pages 157-177

   11. Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury

       • Kunjan R. Dave, John W. Thompson, Jake T. Neumann, Miguel A. Perez-Pinzon, Hung W. Lin

       Pages 179-200

   12. Stem Cells for Neurovascular Repair in CNS Trauma

       • Mibel M. Pabón, Travis Dailey, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Sandra Acosta et al.

       Pages 201-222

   13. Vascular Actions of Hypothermia in Brain Trauma

       • W. Dalton Dietrich, Helen M. Bramlett

       Pages 223-235

3. Experimental Models and Methods

   1. Front Matter

      Pages 237-237

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   2. Vascular Responses in Rodent Models of Traumatic Brain Injury

      • Xiaoshu Wang, Zhanyang Yu, Zhengbu Liao, Qi Liu, MingMing Ning, Xiaochuan Sun et al.

      Pages 239-253

   3. SAH Models: Review, New Modification, and Prospective

      • Sheng Chen, Damon Klebe, Alexander Vakhmyanin, Mutsumi Fujii, John H. Zhang

      Pages 255-267

   4. Age and Sex Differences in Hemodynamics in a Large Animal Model of Brain Trauma

      • William M. Armstead, Monica S. Vavilala

      Pages 269-284

   5. Neutrophils as Determinants of Vascular Stability in the Injured Spinal Cord

      • Alpa Trivedi, Sang Mi Lee, Haoqian Zhang, Linda J. Noble-Haeusslein

      Pages 285-302

   6. Blood Biomarkers for Acute CNS Insults: Traumatic Brain Injury and Stroke

      • Olena Glushakova, Stefania Mondello, Ronald L. Hayes

      Pages 303-331

While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.​

• blood-brain barrier
• cerebral blood flow
• edema
• neuroprotection
• spinal cord injury
• traumatic brain injury

From the reviews:

“This textbook on cerebral blood flow and physiology of head injury is worth reading for graduate students, experts in the head trauma research, and also to seasoned investigators. The work is done for the historical origins, developments over the past 30 years and especially the current literature. … this is an excellent textbook for all neurophysiologists and stroke researchers from student to experts … .” (Joseph J. Grenier, Amazon.com, December, 2013)

• Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, USA

  Eng H. Lo

• Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, USA

  Josephine Lok

• Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, USA

  MingMing Ning

• Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, USA

  Michael J. Whalen

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