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Non-coding RNAs and Cancer

  • Book
  • © 2014

Overview

Editors:
  1. Muller Fabbri

    1. Pediatrics and Molecular Microbiology &, University of Southern California Children's Hospital Los Angeles, Los Angeles, USA

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  • Examines recently identified gene regulatory mechanisms involving non-coding RNAs

  • Provides essential information of the biogenesis, physiology and de-regulation of non-coding RNAs in cancer

  • Guides the reader to the most widely and effectively used bioinformatic approaches to the study of miRNAs

  • Includes supplementary material: sn.pub/extras

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
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  2. Introduction

    • Muller Fabbri
    Pages 1-4

  3. Biogenesis and Physiology of MicroRNAs

    • Carlos A. Melo, Sonia A. Melo
    Pages 5-24

  4. Detecting Noncoding RNA Expression: From Arrays to Next-Generation Sequencing

    • Catalina Perdomo, Joshua Campbell, Frank Schembri
    Pages 25-44

  5. MicroRNAs in Solid Tumors

    • Jin Wang, Subrata Sen
    Pages 45-65

  6. MicroRNAs in Hematologic Malignancies

    • Johannes Bloehdorn, Arefeh Rouhi, Pavan Kumar Dhanyamraju, Kathrin Krowiorz, Edith Schneider, Christian Langer et al.
    Pages 67-95

  7. miRNAs as Cancer Biomarkers

    • Edward R. Sauter
    Pages 97-124

  8. Unraveling the Complex Network of Interactions Between Noncoding RNAs and Epigenetics in Cancer

    • Veronica Davalos, Manel Esteller
    Pages 125-148

  9. MicroRNA SNPs in Cancer

    • Yujing Li, Peng Jin
    Pages 149-163

  10. Bioinformatics Approaches to the Study of MicroRNAs

    • Ravi Gupta, Ramana V. Davuluri
    Pages 165-245

  11. Beyond miRNAs: Role of Other Noncoding RNAs in Cancer

    • Roxana S. Redis, George A. Calin
    Pages 247-264

  12. Translational Implications for Noncoding RNA in Cancer

    • Duaa Dakhallah, Melissa Piper, S. Patrick Nana-Sinkam
    Pages 265-282

  13. Back Matter

    Pages 283-284
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Keywords

About this book

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.

Editors and Affiliations

  • Pediatrics and Molecular Microbiology &, University of Southern California Children's Hospital Los Angeles, Los Angeles, USA

    Muller Fabbri

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