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Molecular Genetics of Inflammatory Bowel Disease

  • Book
  • © 2013

Overview

Editors:
  1. Mauro D'Amato

    1. Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden

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    You can also search for this editor in PubMed   Google Scholar

  2. John D Rioux

    1. Research Center, Montreal Heart Institute, Montreal, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a complete review of existing knowledge of molecular genetics in inflammatory bowel diseases

  • Highlights the latest discoveries from molecular and genome-wide association studies

  • Gives insight into disease pathogenesis and potential targets for pharmaceutical intervention

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xiii
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  2. The Foundation of IBD Genetics, Human and Animal Studies

    1. Front Matter

      Pages 1-1
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    2. A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges

      • Xinjun Cindy Zhu, Richard P. MacDermott
      Pages 3-21

    3. Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies

      • Jonas Halfvarson
      Pages 23-43

    4. Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease

      • Emiko Mizoguchi, Atsushi Mizoguchi, Atul K. Bhan
      Pages 45-83

  3. The Genetic and Molecular Makeup of Inflammatory Bowel Disease

    1. Front Matter

      Pages 85-85
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    2. Complex Disease Genes and Their Discovery

      • Jeffrey C. Barrett, Mark J. Daly
      Pages 87-97

    3. The Genetics of Crohn’s Disease

      • Andre Franke, Miles Parkes
      Pages 99-118

    4. Genetics of Ulcerative Colitis

      • Mauro D’Amato, Catherine Labbé, John D. Rioux
      Pages 119-134

    5. Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases

      • Charlie W. Lees, Alexandra Zhernakova
      Pages 135-150

    6. Molecular Profiling of IBD Subtypes/Response to Therapy

      • Isabelle Cleynen, Séverine Vermeire
      Pages 151-169

    7. Epigenetics of Inflammatory Bowel Disease

      • Robert Häsler, Stefan Schreiber, Stephan Beck, Philip Rosenstiel
      Pages 171-187

  4. Pathogenetic Pathways in Inflammatory Bowel Disease

    1. Front Matter

      Pages 189-189
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    2. Nod1 and Nod2 and the Immune Response to Bacteria

      • Maria Kaparakis-Liaskos, Dana J. Philpott
      Pages 191-217

    3. The IL23-Th17 Axis in Intestinal Inflammation

      • Kevin J. Maloy
      Pages 219-240

    4. Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics

      • Natalia B. Nedelsky, Petric Kuballa, Adam B. Castoreno, Ramnik J. Xavier
      Pages 241-264

    5. The Epithelial Barrier

      • Stefan Koch, Asma Nusrat, Charles A. Parkos
      Pages 265-280

    6. Host Interactions with Bacteria: From “Entente Cordiale” to “Casus Belli”

      • Nouara Lhocine, Philippe J. Sansonetti
      Pages 281-305

    7. Cytokines in Inflammatory Bowel Disease

      • Matthias A. Engel, Markus F. Neurath
      Pages 307-326

  5. Concluding Remarks and Future Perspectives

    1. Front Matter

      Pages 327-327
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About this book

Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis,  multiple sclerosis, type 1 diabetes and many others).

Editors and Affiliations

  • Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden

    Mauro D'Amato

  • Research Center, Montreal Heart Institute, Montreal, Canada

    John D Rioux

Bibliographic Information

  • Book Title: Molecular Genetics of Inflammatory Bowel Disease

  • Editors: Mauro D'Amato, John D Rioux

  • DOI: https://doi.org/10.1007/978-1-4614-8256-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Softcover ISBN: 978-1-4939-4256-5Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8256-7Published: 05 October 2013

  • Edition Number: 1

  • Number of Pages: XIII, 343

  • Number of Illustrations: 23 illustrations in colour

  • Topics: Human Genetics, Molecular Medicine, Biomedicine general

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