Protein Tyrosine Phosphatase Control of Metabolism

1. Front Matter

   Pages i-xi

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2. Redox Regulation of PTPs in Metabolism: Focus on Assays

   • Yang Xu, Benjamin G. Neel

   Pages 1-26

3. Quantitative Modeling Approaches for Understanding the Role of Phosphatases in Cell Signaling Regulation: Applications in Metabolism

   • Matthew J. Lazzara

   Pages 27-48

4. Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism

   • Yannan Xi, Fawaz G. Haj

   Pages 49-69

5. PTP1B and TCPTP in CNS Signaling and Energy Balance

   • Kendra K. Bence, Tony Tiganis

   Pages 71-89

6. PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress

   • Mirela Delibegovic, Nimesh Mody

   Pages 91-105

7. Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling

   • Águeda González-Rodríguez, Ángela M. Valverde

   Pages 107-127

8. PTP1B in Obesity-Related Cardiovascular Function

   • Pimonrat Ketsawatsomkron, David W. Stepp, Eric J. Belin de Chantemèle

   Pages 129-145

9. Role of the SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism

   • Maria I. Kontaridis, Eleni V. Geladari, Charalampia V. Geladari

   Pages 147-167

10. Metabolic Effects of Neural and Pancreatic Shp2

    • Zhao He, Sharon S. Zhang, Jianxiu Yu, Gen-Sheng Feng

    Pages 169-186

11. Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism

    • Ari Elson

    Pages 187-202

12. The Role of LMPTP in the Metabolic Syndrome

    • Stephanie M. Stanford, Massimo Bottini, Nunzio Bottini

    Pages 203-220

13. Mitogen-Activated Protein Kinase Phosphatases in Metabolism

    • Ahmed Lawan, Anton M. Bennett

    Pages 221-238

14. Glycogen Metabolism and Lafora Disease

    • Peter J. Roach, Anna A. DePaoli-Roach

    Pages 239-262

15. Back Matter

    Pages 263-273

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Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.

• Department of Animal Biology, University of Pennsylvania, Philadelphia, USA

  Kendra K. Bence

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