Stem Cells Handbook

1. Front Matter

   Pages i-xvi

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2. Introduction to Stem Cells

   • Rob Burgess

   Pages 1-27

3. Contemporary Ethical Issues in Stem Cell Research

   • Valerie Gutmann Koch, Beth E. Roxland, Barbara Pohl, Sarah K. Keech

   Pages 29-37

4. Embryonic/Fetal Stem Cells

   1. Front Matter

      Pages 39-39

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   2. Stem Cells from Early Mammalian Embryos

      • Anna-Katerina Hadjantonakis, Svetlana Gavrilov, Panagiotis Xenopoulos, Virginia E. Papaioannou

      Pages 41-57

   3. Quantitative Approaches to Model Pluripotency and Differentiation in Stem Cells

      • Dmitri Papatsenko, Huilei Xu, Avi Ma’ayan, Ihor Lemischka

      Pages 59-74

   4. Growth Dynamics of Fetal Human Neural Stem Cells

      • Walter D. Niles, Dustin R. Wakeman, Evan Y. Snyder

      Pages 75-89

   5. Immunobiology of Embryonic and Induced Pluripotent Stem Cell Transplantation

      • Eleanor M. Bolton, J. Andrew Bradley, Craig J. Taylor

      Pages 91-104

5. Pluripotent Stem Cells

   1. Front Matter

      Pages 105-105

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   2. Urodele Limb Regeneration: Mechanisms of Blastema Formation and Growth

      • David L. Stocum

      Pages 107-117

   3. Mechanism of miR-302-Mediated iPS Cell Generation

      • Shi-Lung Lin

      Pages 119-127

   4. Bioreactor Expansion of Pluripotent Stem Cells

      • Jaymi T. Taiani, Mehdi Shafa, Derrick E. Rancourt

      Pages 129-138

   5. Generation of Hepatocyte-Like Cells from Human Pluripotent Stem Cells

      • Fallon K. Noto, Stephen A. Duncan

      Pages 139-147

   6. Neural Differentiation from Pluripotent Stem Cells

      • Mahendra Rao, Nasir Malik

      Pages 149-160

   7. Generation of Anterior Foregut Derivatives from Pluripotent Stem Cells

      • Hans-Willem Snoeck

      Pages 161-175

   8. Commercial Opportunities for Induced Pluripotent Stem Cells

      • Amy Lynnette Van Deusen, Rania Nasis

      Pages 177-199

6. Tissue Stem Cells

   1. Front Matter

      Pages 201-201

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   2. Spermatogonial Stem Cells in Adult Mice and Men

      • Courtney Sachs, Marco Seandel

      Pages 203-210

   3. Characterization of the Hematopoietic Stem Cell Niche: Cellular and Molecular Analysis

      • Charles Durand, Thomas Häupl, Pierre Charbord

      Pages 211-221

   4. Glandular Stem Cells (GSCs): Stem Cells in Glandular Organs

      • Ming Jiang, Karin Williams, Simon W. Hayward

      Pages 223-233

This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells. 

• Embryonic cells
• Fetal stem cells
• Mesenchymal stem cells
• Totipotential stem cells
• iPSCs

• New York State Health Department Wadsworth Center, Albany, USA

  Stewart Sell

Dr. Sell is a board certified pathologist and immunologist. He began research in 1957 while a medical student at the University of Pittsburgh, in the Department of Pathology, under Frank J. Dixon. After a pathology residency at Massachusetts Hospital, and post doctoral fellowships at NIH and Birmingham England he returned to the University of Pittsburgh for 5 years before moving to the University of California at San Diego. After 12 years at UCSD, Dr. Sell took the position as Chair of Pathology and Laboratory Medicine at the University of Texas (UT) at Houston before moving to Albany Medical College. As of February 2003 he has been a senior scientist at Wadsworth Center, a Professor at University at Albany School of Public Health and an Adjunct Professor at Albany College of Pharmacy. Dr. Sell received the Rudolph L. K. Virchow Award of the Italian Medical Magazine LeadershipMedica.com for his concept of cancer stem cells; he was named Legacy Laureate of the University of Pittsburgh for his work on alpha-fetoprotein as a marker for liver cancer; and in 2007 received the Abbott Award of the International Society for Oncodevelopmental Biology and Medicine for recognizing the role of stem cells in carcinogenesis. He has published over 400 papers and 12 books, including 6 editions of Immunology, Immunopathology and Immunity. His paper with Barry Pierce (Lab. Invest. 70:6-21, 1994.) was selected as an AACR scientific landmark.

Policies and ethics