Adipose Tissue and Cancer

1. Front Matter

   Pages i-viii

   PDF

2. Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity–Cancer Link

   • Nikki A. Ford, John DiGiovanni, Stephen D. Hursting

   Pages 1-14

3. Increased Adiposity and Colorectal Cancer

   • Charles Bellows, Herbert Tilg

   Pages 15-32

4. Adiposity and Diabetes in Breast and Prostate Cancer

   • Linda Vona-Davis, David P. Rose

   Pages 33-51

5. Increased Adiposity and Endometrial Cancer Risk

   • Karen H. Lu, Ann H. Klopp, Pamela T. Soliman, Rosemarie E. Schmandt

   Pages 53-69

6. Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer

   • Gilberto Paz-Filho, Ameet Kumar Mishra, Julio Licinio

   Pages 71-97

7. Animal Models to Study the Interplay Between Cancer and Obesity

   • Amitabha Ray, Margot P. Cleary

   Pages 99-119

8. Unraveling the Local Influence of Tumor-Surrounding Adipose Tissue on Tumor Progression: Cellular and Molecular Actors Involved

   • Catherine Muller, Laurence Nieto, Philippe Valet

   Pages 121-146

9. Trafficking of Cells from Adipose Tissue to Tumor Microenvironment

   • Ines Martin-Padura, Patrizia Mancuso, Francesco Bertolini

   Pages 147-163

10. The Impact of Obesity Intervention on Cancer: Clinical Perspectives

    • Ted D. Adams, Jessica L. J. Greenwood, Steven C. Hunt

    Pages 165-187

11. Back Matter

    Pages 189-190

    PDF

Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. The goal of this book is to discuss data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression.

• adipocytes
• adipokines
• adiposity
• metabolic dysregulation
• white adipose tissue

• Science Center at Houston, Inst. Molecular Medicine, University of Texas, Houston, USA

  Mikhail G. Kolonin

Policies and ethics