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Response and Adaptation to Hypoxia

Organ to Organelle

  • Book
  • © 1991

Overview

Editors:
  1. Sukhamay Lahiri

    1. Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, USA

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  2. Neil S. Cherniack

    1. Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Robert S. Fitzgerald

    1. Departments of Environmental Health, Sciences and of Physiology, The Johns Hopkins Medical Institutions, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Covers the physiological responses and adaptations to hypoxia
  • The book emphasizes the molecular and cellular mechanisms
  • This book provides a useful reference for physiologists and other blood biologists, as well as pulmonary physicians

Part of the book series: Clinical Physiology (CLINPHY)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xi
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  2. Mitochondrial Response and Adaptation to Hypoxia

    1. Front Matter

      Pages 1-1
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    2. Respiratory System Adaptation to Hypoxia: Lung to Mitochondria

      • Ewald R. Weibel, Hans Hoppeler
      Pages 3-13

    3. Factors Affecting Adaptation of the Mitochondrial Enzyme Content to Cellular Needs

      • David F. Wilson, William L. Rumsey
      Pages 14-24

    4. Regulation of Mitochondrial Distribution: An Adaptive Response to Changes in Oxygen Supply

      • Dean P. Jones, Tak Yee Aw, Changli Bai, A. H. Sillau
      Pages 25-35

  3. Cell and Molecular Biology of Erythropoietin

    1. Front Matter

      Pages 37-37
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    2. Control of the Production of Erythropoietin by a Renal Oxygen-Sensor?

      • Wolfgang Jelkmann, Horst Pagel, Christoph Weiss
      Pages 39-47

    3. Hypoxia and Erythropoietin Production

      • James W. Fisher, M. Ueno, J. Nakashima, Barbara Beckman
      Pages 48-62

    4. Regulating Mechanisms Involved in the Expression of the Erythropoietin Gene

      • Jaime Caro, Stephen Schuster, Bassam Fraij, Sylvia Ramirez
      Pages 63-68

    5. Expression of the Erythropoietin Gene in the Kidney and the Liver of the Anemic Mouse

      • C. Lacombe, J. L. Da Silva, P. Bruneval, C. Chesne, A. Guillouzo, J. P. Camilleri et al.
      Pages 69-77

  4. Cell Biology and Functions of Peripheral Chemoreceptors

    1. Front Matter

      Pages 79-79
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    2. Oxygen Sensing by Arterial Chemoreceptors

      • Ashima Anand, A. S. Paintal
      Pages 81-94

    3. Oxygen Biology of Peripheral Chemoreceptors

      • Sukhamay Lahiri
      Pages 95-106

    4. Excitatory and Inhibitory Influences on the Ventilatory Augmentation Caused by Hypoxia

      • Neil S. Cherniack, Nanduri Prabhakar, Musa A. Haxhiu, Michael Runold
      Pages 107-121

    5. Control of Ventilation in Chronic Hypoxia Role of Peripheral Chemoreceptors

      • John V. Weil
      Pages 122-132

    6. Molecular Mechanisms of Carotid Body Afferent Neuron Development

      • David M. Katz
      Pages 133-142

    7. Relationship Between Erythropoiesis and Ventilation in High Altitude Natives

      • Robert M. Winslow
      Pages 143-153

  5. Oxygen Biology of Adaptation

    1. Front Matter

      Pages 155-155
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    2. Geometrical Relationship Between Capillaries and Muscle Fibers in Chronic Hypoxia

      • Odile Mathieu-Costello
      Pages 157-166

    3. Muscle Function at Altitude

      • P. Cerretelli, B. Kayser, H. Hoppeler, D. Pette
      Pages 167-176
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Keywords

About this book

The underlying theme of this book is the biology of oxygen. The 22 chapters cover aspects of molecular, cellular, and integrative physiological functions. A fundamental evolutionary feature of the oxygen-consuming organism is that it developed a oxygen-sensing mechanism as apart of feedback control at the levels of molecules, organelles, organs, and systems. Oxygen sensing is partic­ ularly expressed in certain specific cells and tissues like peripheral chemore­ ceptors, erythroprotein-producing cells, and vascular smooth muscle. Apart of the book is focused on the current issues of this basic question of chemosen­ sing. Mitrochondria as the major site for cellular oxygen consumption is a nat­ ural candidate for cellular oxygen sensitivity and adaptation. A section deals with this question. A perennial question concerns chronic environment al oxy­ gen and the organism's response and adaptation to it. This theme runs through several chapters. Because comparative physiology often provides insight into the mechanisms of environment al adaptation, a chapter on respiration of high altitude birds has been incorporated. Obviously this book gives only glimpses of the immense field of oxygen biology. The book grew out of two meetings where these subjects were discussed. These meetings were sponsored by the American Physiological Society and the Federation of American Societies for Experimental Biology. We are grateful to the FASEB Program Committee and APS publication committee for their sup­ port. We owe much to Ms. Anne Miller for her editorial assistance. S. L. Philadelphia N. S . C. Cleveland R. S. F.

Editors and Affiliations

  • Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, USA

    Sukhamay Lahiri

  • Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, USA

    Neil S. Cherniack

  • Departments of Environmental Health, Sciences and of Physiology, The Johns Hopkins Medical Institutions, Baltimore, USA

    Robert S. Fitzgerald

Bibliographic Information

  • Book Title: Response and Adaptation to Hypoxia

  • Book Subtitle: Organ to Organelle

  • Editors: Sukhamay Lahiri, Neil S. Cherniack, Robert S. Fitzgerald

  • Series Title: Clinical Physiology

  • DOI: https://doi.org/10.1007/978-1-4614-7574-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: American Physiological Society 1991

  • eBook ISBN: 978-1-4614-7574-3Published: 27 May 2013

  • Edition Number: 1

  • Number of Pages: 264

  • Additional Information: Originally Published by Oxford University Press 1991

  • Topics: Human Physiology

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