Skip to main content
SpringerLink
Log in

Membrane Protein Structure

Experimental Approaches

  • Book
  • © 1994

Overview

Editors:
  1. Stephen H. White

    1. College of Medicine, Department of Physiology and Biophysics, University of California, Irvine, Irvine, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Focuses on membrane protein structure
  • The reviews presented here emphasize fundamental ideas and provide an entry to the diverse and complex literature
  • The four major sections deal with the general nature of the membrane protein structure problem, biochemical and molecular biological approaches to protein topology, direct structural methods, and model and physicochemical approaches
  • The work will be of interest to physiologists, cellular and molecular biologists, biophysicists, and biochemists

Part of the book series: Methods in Physiology (METHPHYS)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The Nature of the Membrane Protein Structure Problem

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Membrane Protein Structure and Stability: Implications of the First Crystallographic Analyses

      • D. C. Rees, A. J. Chirino, K.-H. Kim, H. Komiya
      Pages 3-26

    3. Decoding the Signals of Membrane Protein Sequences

      • Gunnar von Heijne
      Pages 27-40

    4. Folding and Assembly of Integral Membrane Proteins: An Introduction

      • Jean-Luc Popot, Catherine de Vitry, Ariane Atteia
      Pages 41-96

    5. Hydropathy Plots and the Prediction of Membrane Protein Topology

      • Stephen H. White
      Pages 97-124

  3. Biochemical and Molecular Biological Approaches: Protein Topology

    1. Front Matter

      Pages 125-126
      Download chapter PDF

    2. Experimental Determination of the Topography of Membrane Proteins: Lessons from the Nicotinic Acetylcholine Receptor, a Multisubunit Polytopic Protein

      • David S. Cafiso
      Pages 127-143

    3. Use of Gene Fusions to Determine Membrane Protein Topology

      • Dana Boyd
      Pages 144-163

    4. Structure of F0F1ATPases Determined by Direct and Indirect Methods

      • L. Mario Amzel, Mario A. Blanchet, Peter L. Pedersen
      Pages 164-177

  5. Model and Physicochemical Approaches

    1. Front Matter

      Pages 281-281
      Download chapter PDF

    2. Physical Studies of Peptide—Bilayer Interactions

      • Lukas K. Tamm
      Pages 283-313

    3. Membrane Protein Structure: Lessons from Gramicidin

      • G. Andrew Woolley, B. A. Wallace
      Pages 314-334

    4. Use of Synthetic Peptides for the Study of Membrane Protein Structure

      • J. D. Lear, Z. R. Wasserman, W. F. Degrado
      Pages 335-354
Back to top

Keywords

About this book

Studies of receptors, ion channels, and other membrane proteins require a solid understanding of the structural principles of these important biomolecules. Membrane protein structure is, however, a very challenging field. The structures of only three types of transmembrane proteins have been determined to moderate or high resolution during the last two decades, a period during which the amino acid sequences of hundreds, if not thousands, of membrane proteins have been reported. As a result, the creation of structural models to serve as guides for studies of receptors, channels, and other membrane proteins has become crucially important. This book has been assembled in order to share the experiences and findings of expert researchers in protein structure and structure-prediction methods as well as membrane biophysics and lipid physical chemistry, whose work establishes the basis for the development of suitable model structures. The reviews presented here emphasize fundamental ideas and provide an entry to the diverse and complex literature. The four major sections deal with the general nature of the membrane protein structure problem, biochemical and molecular biological approaches to protein topology, direct structural methods, and model and physicochemical approaches. The work will be of interest to physiologists, cellular and molecular biologists, biophysicists, and biochemists working on the function of membrane proteins such as receptors, ion channels, and transporters, as well as senior graduate students and independent investigators.

Editors and Affiliations

  • College of Medicine, Department of Physiology and Biophysics, University of California, Irvine, Irvine, USA

    Stephen H. White

Bibliographic Information

  • Book Title: Membrane Protein Structure

  • Book Subtitle: Experimental Approaches

  • Editors: Stephen H. White

  • Series Title: Methods in Physiology

  • DOI: https://doi.org/10.1007/978-1-4614-7515-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: American Physiological Society 1994

  • eBook ISBN: 978-1-4614-7515-6Published: 27 May 2013

  • Series ISSN: 2628-7471

  • Series E-ISSN: 2628-748X

  • Edition Number: 1

  • Number of Pages: 416

  • Additional Information: Originally Published by Oxford University Press 1994

  • Topics: Cell Physiology

Publish with us

Policies and ethics

Back to top

Search

Navigation