Endothelin

1. Front Matter

   Pages i-1

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2. Endothelium-Derived Contracting Factors

   • Paul M. Vanhoutte, Thomas Gräser, Thomas F. Lüscher

   Pages 3-16

3. From Endotensin to Endothelin: The Discovery and Characterization of an Endothelial Cell—Derived Constricting Factor

   • Robert F. Highsmith

   Pages 17-30

4. Molecular Biology of Endothelins

   • Penny E. Phillips, Christina Cade, Lynne H. Parker Botelho, Gabor M. Rubanyi

   Pages 31-40

5. Endothelin Structure and Structure—Activity Relationships

   • Paul W. Erhardt

   Pages 41-57

6. Endothelin Receptors and Receptor Subtypes

   • Hitoshi Miyazaki, Motohiro Kondoh, Yasushi Masuda, Hirotoshi Watanabe, Kazuo Murakami

   Pages 58-71

7. Tissue Specificity of Endothelin Synthesis and Binding

   • Lynne H. Parker Botelho, Christina Cade, Penny E. Phillips, Gabor M. Rubanyi

   Pages 72-102

8. Cellular Actions of Endothelin in Vascular Smooth Muscle

   • Tommy A. Brock, N. Raju Danthuluri

   Pages 103-124

9. Interaction between Endothelin and Endothelium-Derived Relaxing Factor(s)

   • Thomas F. Lüscher, Chantal Boulanger, Zhihong Yang, Yasuaki Dohi

   Pages 125-136

10. Endothelin as a Growth Factor in Vascular Remodeling and Vascular Disease

    • Victor J. Dzau, Richard E. Pratt, John P. Cooke

    Pages 137-143

11. Endothelin and the Heart

    • Winifred G. Nayler, Xin Hua Gu

    Pages 144-157

12. Renal and Systemic Hemodynamic Actions of Endothelin

    • Andrew J. King, Barry M. Brenner

    Pages 158-178

13. Endothelin, a Ubiquitous Peptide: Morphological Demonstration of Immunoreactive and Synthetic Sites and Receptors in the Respiratory Tract and Central Nervous System

    • S. J. Gibson, D. R. Springall, Julia M. Polak

    Pages 179-208

14. Endothelin in Human Disease. I: Essential Hypertension, Vasospastic Angina, Acute Myocardial Infarction, and Chronic Renal Failure

    • Yoshihiko Saito, Kazuwa Nakao, Hiroo Imura

    Pages 209-220

15. Endothelin in Human Disease. II: Shock, Pulmonary Hypertension, and Congestive Heart Failure

    • Duncan J. Stewart

    Pages 221-237

16. Endothelin and the Homeostatic Function of the Endothelial Cell

    • Regina M. Botting, John R. Vane

    Pages 238-257

17. Hypothetical Role of Endothelin in the Control of the Cardiovascular System

    • Gabor M. Rubanyi, John T. Shepherd

    Pages 258-271

18. Back Matter

    Pages 273-277

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Merely three years after the discovery of endothelin, a large amount of information has been generated about the molecular biology, biosynthesis, biological actions and potential physiological and pathological importance of this unique peptide and its isoforms. This first book on endothelins summarizes the early events which lead to the discovery of endothelin, the progress made in understanding the peptide's physiological role, and the current state-of-the-art in contemporary endothelin research. The book also discusses the potential significance of endothelins in health and disease, covers the potential role of the peptides in the integrated control of the cardiovascular system, and outlines future research directions. This comprehensive monograph is an indispensable reference for basic scientists and clinicians.

• Endothelin
• biology
• cardiovascular
• cardiovascular system
• central nervous system
• endothelium
• heart
• heart failure
• hypertension
• myocardial infarction
• physiology
• smooth muscle
• tissue
• vascular disease

• Institute of Pharmacology, Research Center, Schering AG, Berlin, Germany

  Gabor M. Rubanyi

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