Human Interphase Chromosomes

1. Front Matter

   Pages i-xvii

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2. Introduction to Interphase Molecular Cytogenetics

   • Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov

   Pages 1-8

3. Interphase Chromosome Behavior in Normal and Diseased Cells

   • Gemma Bourne, Catherine Moir, Ural Bikkul, Mai Hassan Ahmed, Ian R. Kill, Christopher H. Eskiw et al.

   Pages 9-33

4. Nuclear Architecture, Chromosome Aberrations, and Genetic Damage

   • Gustavo A. Folle, María Vittoria Di Tomaso, Laura Lafon-Hughes, Pablo Liddle

   Pages 35-51

5. Interphase Chromosomes of the Human Brain: The Biological and Clinical Meaning of Neural Aneuploidy

   • Ivan Y. Iourov, Svetlana G. Vorsanova, Yuri B. Yurov

   Pages 53-83

6. Differentiating Chromosome Fragmentation and Premature Chromosome Condensation

   • Joshua B. Stevens, Henry H. Q. Heng

   Pages 85-105

7. Chromosomes and Nuclear Organization in ICF Syndrome

   • Emanuela V. Volpi

   Pages 107-121

8. Interphase Cytogenetics at the Earliest Stages of Human Development

   • Darren K. Griffin, Gothami Fonseka, Helen G. Tempest, Alan R. Thornhill, Dimitris Ioannou

   Pages 123-138

9. Organization of Chromosomes in Human Sperm Nucleus

   • Olga S. Mudrak, Liudmila V. Solovjeva, Vadim O. Chagin

   Pages 139-159

10. Interphase Chromosome-Specific Multicolor Banding

    • Ivan Y. Iourov, Thomas Liehr, Svetlana G. Vorsanova, Yuri B. Yurov

    Pages 161-169

11. Chromosome Architecture Studied by High-Resolution FISH Banding in Three Dimensionally Preserved Human Interphase Nuclei

    • Thomas Liehr, Hasmik Mkrtchyan, Marina Manvelyan, Tatyana Karamysheva, Elisabeth Klein, Samarth Bhatt

    Pages 171-178

12. Technological Solutions in Human Interphase Cytogenetics

    • Svetlana G. Vorsanova, Yuri B. Yurov, Ivan Y. Iourov

    Pages 179-203

13. Back Matter

    Pages 205-216

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This title will focus on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and human genome function in interphase nuclei at the chromosomal level have been repeatedly shown to play a significant role in a variety of basic biological processes involved in realization and inheritance of genetic information within and between species. Current biomedical sciences of post-genomic era refocus basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease.   Additionally, related processes are a target of studies elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation etc. Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze  interphase nuclei are closely associated with application of these techniques in clinical, diagnostic and research practice to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This title will serve as a source of new valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology. ​

• chromosome
• cytogenetics
• developmental biology
• genetics

• Mental Health Research Center, Laboratory of Cytogenetics, Russian Academy of Medical Sciences, Moscow, Russia

  Yuri B. Yurov

• Institute of Pediatry & Children Surgery, Laboratory of Molecular Cytogenetics of, Ministry of Health, Moscow, Russia

  Svetlana G. Vorsanova

• Mental Health Research Center, Laboratory of Molecular Brain Genetics, Russian Academy of Medical Sciences, Moscow, Russia

  Ivan Y. Iourov

^400 publications.

 

Svetlana G. Vorsanova (PhD, Dr. Sci, professor) is a head of laboratory of molecular cy^600 publications.

 

Yuri B. Yurov (PhD, Dr. Sci, professor; 1951-2017) was a pioneer of interphase molecular cytogenetics. He was the founding editor of Molecular Cytogenetics (BMC/Springer/Nature). He has (co-)authored >650 publications, including descriptions of groundbreaking studies in molecular cytogenetics of the human brain.

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