Vesicle Trafficking in Cancer

1. Front Matter

   Pages i-xiv

   PDF

2. Clathrin-Mediated Endocytosis

   • Alexander Sorkin, Manojkumar A. Puthenveedu

   Pages 1-31

3. Intimate and Facultative? Regulation of Clathrin-Mediated Endocytosis by the Actin Cytoskeleton

   • Tal Hirschhorn, Marcelo Ehrlich

   Pages 33-56

4. Oncogenic Signaling from the Plasma Membrane

   • Eli Zamir, Nachiket Vartak, Philippe I. H. Bastiaens

   Pages 57-74

5. Endocytosis in the Spatial Control of Polarised Cell Functions

   • Giorgio Scita, Andrea Disanza, Emanuela Frittoli, Andrea Palamidessi, Sara Sigismund

   Pages 75-94

6. Aberrant Vesicular Trafficking Contributes to Altered Polarity and Metabolism in Cancer

   • Shreya Mitra, Gordon B. Mills

   Pages 95-123

7. Endocytosis and the Regulation of Cell Signaling, Cell Adhesion, and Epithelial to Mesenchymal Transition in Cancer

   • Crislyn D’Souza-Schorey, Guangpu Li

   Pages 125-138

8. Efficient Enhancement of Signaling Capacity: Signaling Endosomes

   • Iwona Pilecka, Marta Miaczynska

   Pages 139-157

9. Nuclear Functions and Trafficking of Receptor Tyrosine Kinases

   • Ying-Nai Wang, Jennifer L. Hsu, Mien-Chie Hung

   Pages 159-176

10. Efficient Enhancement of Signalling Capacity: The Ubiquitin System

    • Daniela Hoeller, Ivan Dikic

    Pages 177-190

11. Molecular Mechanism of Ubiquitin-Dependent Traffic

    • Elena Maspero, Hans-Peter Wollscheid, Simona Polo

    Pages 191-218

12. Cbl as a Master Regulator of Receptor Tyrosine Kinase Trafficking

    • Ke Ma, Stephen C. Kales, Marion M. Nau, Stanley Lipkowitz

    Pages 219-244

13. Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes

    • Han Liu, Sylvie Urbé, Michael J. Clague

    Pages 245-259

14. RTKs as Models for Trafficking Regulation: c-Met/HGF Receptor-c-Met Signalling in Cancer—Location Counts

    • Carine Joffre, Rachel Barrow, Ludovic Ménard, Stéphanie Kermorgant

    Pages 261-277

15. Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis in Normal and Malignant Cells

    • Sergio Anastasi, Stefano Alemà, Oreste Segatto

    Pages 279-302

16. Stress-Driven Endocytosis of Tyrosine-Phosphorylated EGFR Leads to Tumorigenesis: The Critical Role of Oxidative Stress

    • Tzipora Goldkorn, Simone Filosto, Samuel Chung

    Pages 303-325

17. Internalisation, Endosomal Trafficking and Recycling of Integrins During Cell Migration and Cancer Invasion

    • Elena Rainero, Peter V. E. van den Berghe, Jim C. Norman

    Pages 327-359

18. Antibody-Mediated Receptor Endocytosis: Harnessing the Cellular Machinery to Combat Cancer

    • Gabi Tarcic, Yosef Yarden

    Pages 361-384

19. Back Matter

    Pages 385-393

    PDF

Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

• C-Met signaling
• endocytosis
• endosomal pathway
• oxidative stress
• Receptors

• Department of Biological Regulation, Rehovot, Israel

  Yosef Yarden

• , Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

  Gabi Tarcic

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