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Kisspeptin Signaling in Reproductive Biology

  • Book
  • © 2013

Overview

Editors:
  1. Alexander S. Kauffman

    1. , Department of Reproductive Medicine, University of California, San Diego, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Jeremy T. Smith

    1. School of Anatomy, Physiology and Human Biology, The University of Western Australia, Nedlands, Australia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Focuses on kisspeptin and its role in reproductive biology
  • Looks at interactions between Kisspeptin and Neurokinin B
  • Reviews model systems for studying kisspeptin signaling
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 784)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xii
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  2. Kisspeptin Signaling In Vivo and In Vitro

    1. Front Matter

      Pages 1-1
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    2. Kisspeptin: Past, Present, and Prologue

      • Robert A. Steiner
      Pages 3-7

    3. Structure, Synthesis, and Phylogeny of Kisspeptin and its Receptor

      • Shinji Kanda, Yoshitaka Oka
      Pages 9-26

    4. Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects

      • Michael N. Lehman, Stanley M. Hileman, Robert L. Goodman
      Pages 27-62

    5. The Effects of Kisspeptin on Gonadotropin Release in Non-human Mammals

      • Ali Abbara, Risheka Ratnasabapathy, Channa N. Jayasena, Waljit S. Dhillo
      Pages 63-87

    6. Effects of Kisspeptin on Hormone Secretion in Humans

      • Yee-Ming Chan
      Pages 89-112

    7. Kisspeptin Excitation of GnRH Neurons

      • Oline K. Rønnekleiv, Martin J. Kelly
      Pages 113-131

    8. Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations

      • Suzy Drummond Carvalho Bianco, Ursula B. Kaiser
      Pages 133-158

    9. Kisspeptin Antagonists

      • Antonia Kathryn Roseweir, Robert P. Millar
      Pages 159-186

    10. Kisspeptin and Clinical Disorders

      • Letícia Gontijo Silveira, Ana Claudia Latronico, Stephanie Beth Seminara
      Pages 187-199

    11. Beyond the GnRH Axis: Kisspeptin Regulation of the Oxytocin System in Pregnancy and Lactation

      • Victoria Scott, Colin H. Brown
      Pages 201-218

  3. Development and Regulation of Kisspeptin Neurons

    1. Front Matter

      Pages 219-219
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    2. The Development of Kisspeptin Circuits in the Mammalian Brain

      • Sheila J. Semaan, Kristen P. Tolson, Alexander S. Kauffman
      Pages 221-252

    3. Kisspeptin and Puberty in Mammals

      • Ei Terasawa, Kathryn A. Guerriero, Tony M. Plant
      Pages 253-273

    4. Sex Steroid Regulation of Kisspeptin Circuits

      • Jeremy T. Smith
      Pages 275-295

    5. Kisspeptin and GnRH Pulse Generation

      • Hiroaki Okamura, Hiroko Tsukamura, Satoshi Ohkura, Yoshihisa Uenoyama, Yoshihiro Wakabayashi, Kei-ichiro Maeda
      Pages 297-323

    6. Interactions Between Kisspeptins and Neurokinin B

      • Víctor M. Navarro
      Pages 325-347

    7. Electrophysiology of Kisspeptin Neurons

      • Meenakshi Alreja
      Pages 349-362

    8. Metabolic Regulation of Kisspeptin

      • Juan Manuel Castellano, Manuel Tena-Sempere
      Pages 363-383
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About this book

Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood.  This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known.  The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function.  Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.

Editors and Affiliations

  • , Department of Reproductive Medicine, University of California, San Diego, La Jolla, USA

    Alexander S. Kauffman

  • School of Anatomy, Physiology and Human Biology, The University of Western Australia, Nedlands, Australia

    Jeremy T. Smith

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