Pathobiology of Cancer Regimen-Related Toxicities

1. Front Matter

   Pages i-x

   PDF

2. General Concepts Affecting Regimen-Related Toxicities

   1. Front Matter

      Pages 1-1

      PDF

3. General concepts affecting regimen-related toxicities

   1. Epidemiology and Outcomes of Regimen-Related Toxicities

      • Linda S. Elting, Yu-Chia Chang, Pratibha Parelkar

      Pages 3-17

   2. The Biological Basis for Differences in Normal Tissue Response to Radiation Therapy and Strategies to Establish Predictive Assays for Individual Complication Risk

      • Christian Nicolaj Andreassen

      Pages 19-33

   3. The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance

      • Edouard I. Azzam, Sonia M. de Toledo, Andrew L. Harris, Vladimir Ivanov, Hongning Zhou, Sally A. Amundson et al.

      Pages 35-61

   4. The Role of Genes on the Metabolism of Chemotherapeutic Agents and Their Impact on Toxicity

      • Young S. Yi, Gil Alterovitz

      Pages 63-73

   5. Animal Models of Regimen-Related Toxicities

      • Gregory Lyng, Richard Logan, Maria Mancini

      Pages 75-95

4. The Pathobiology of Specific Toxicities

   1. Front Matter

      Pages 97-97

      PDF

   2. Nausea and Vomiting

      • Pernille H. Hansen, Jesper Palshof, Jørn Herrstedt

      Pages 99-119

   3. Mucositis

      • Noor Al-Dasooqi, Dorothy M. Keefe, Dorothy M. Keefe, Stephen T. Sonis

      Pages 121-146

   4. Dermatitis and Alopecia

      • Yevgeniy Balagula, Mario E. Lacouture

      Pages 147-166

   5. Fibrosis

      • Lynne A. Murray, Matthew A. Sleeman

      Pages 167-186

   6. Myelosuppression

      • David C. Dale

      Pages 187-205

   7. Neuropathy

      • Elizabeth K. Joseph

      Pages 207-215

   8. Mechanisms of Cancer Related Fatigue

      • Jonathan A. Zombeck

      Pages 217-232

   9. Xerostomia

      • Ana P. Cotrim, Changyu Zheng, Bruce J. Baum

      Pages 233-248

   10. Osteonecrosis

       • Caterina Musolino, Alessandro Allegra

       Pages 249-282

5. Conclusions and Therapeutic Opportunities

   1. Front Matter

      Pages 283-283

      PDF

6. Conclusions and therapeutic opportunities

   1. Conclusion

      • Stephen T. Sonis, Stephen T. Sonis, Stephen T. Sonis, Dorothy M. Keefe, Dorothy M. Keefe, Dorothy M. Keefe et al.

      Pages 285-286

7. Back Matter

   Pages 287-292

   PDF

The contents of this book will be organized into three sections. The first section defines the scope, impact and behaviour of cancer regimen-related toxicities and frames the issue of balancing treatment success and physiological cost. In the second segment of the book, the most current thinking around the pathobiology of specific, common, and representative toxicities is presented by leading researchers and translational scientists. The final portion of the book discusses the common biological relationships between toxicities, bioinformatical approaches to analysing key and common pathways, and strategies for the development of effective interventions.

• Bioinformatics
• Cancer Research
• Cancer Research
• Pharmacology
• Toxicology

• Brigham and Women’s Hospital, Boston, USA

  Stephen T. Sonis

• Royal Adelaide Hospital, Adelaide, Australia

  Dorothy M. Keefe

Policies and ethics