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The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence

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  • © 2012

Overview

Editors:
  1. Monica E. Embers

    1. Covington, USA

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  • This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host
  • Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites
  • Addresses antibiotic therapy for control of infection, a baffling topic that lends itself to exalted interpretation
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Invasion and Dissemination

    1. Front Matter

      Pages 1-1
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    2. Treponema pallidum Dissemination; Facilitating Immune Evasion and Bacterial Persistence

      • Simon Houston, Caroline E. Cameron
      Pages 3-18

    3. Immunoseclusion and Chronic Infection by Borrelia burgdorferi

      • Robert D. Gilmore Jr.
      Pages 19-39

  3. Immune Evasion

    1. Front Matter

      Pages 41-41
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    2. Treponema denticola: FhbB, Dentilisin, Complement Evasion and the Paradox of Factor H Cleavage

      • John V. McDowell, Daniel P. Miller, Katherine L. Mallory, Richard T. Marconi
      Pages 43-62

    3. Borrelial Complement-Binding Proteins

      • Peter Kraiczy, Reinhard Wallich
      Pages 63-88

    4. Treponema pallidum Repeat (tpr) Genes and Antigenic Variation

      • Lorenzo Giacani, Arturo Centurion-Lara
      Pages 89-111

    5. Antigenic Variation of VlsE in Borrelia burgdorferi

      • Troy Bankhead
      Pages 113-123

    6. Modulation of Cytokine Signaling by B. burgdorferi

      • Vida A. Dennis, Aarti Gautam, Saurabh Dixit
      Pages 125-141

    7. Leptospira: Invasion, Pathogenesis and Persistence

      • Syed M. Faisal, Sean P. McDonough, Yung-Fu Chang
      Pages 143-172

    8. Immune Resistance by Relapsing Fever Spirochetes

      • Monica E. Embers, Job E. Lopez
      Pages 173-191

  4. Persistence

    1. Front Matter

      Pages 193-193
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    2. Neuroborreliosis Caused by Borrelia burgdorferi: Possible Role of Glial Cells

      • Mario T. Philipp, Geeta Ramesh, Geetha Parthasarathy
      Pages 195-212

    3. Antibiotic Resistance in Treponema pallidum subsp. pallidum, the Syphilis Agent

      • Lola V. Stamm
      Pages 213-228

    4. Borrelia burgdorferi Persistence Post-antibiotic Treatment

      • Monica E. Embers, Stephen W. Barthold
      Pages 229-257

  5. Back Matter

    Pages 259-265
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Keywords

About this book

​This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host.  Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites.  We also explore antibiotic therapy for control of infection, a baffling topic that lends itself to exalted interpretation.

Editors and Affiliations

  • Covington, USA

    Monica E. Embers

Bibliographic Information

  • Book Title: The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence

  • Editors: Monica E. Embers

  • DOI: https://doi.org/10.1007/978-1-4614-5404-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2012

  • Hardcover ISBN: 978-1-4614-5403-8Published: 07 December 2012

  • Softcover ISBN: 978-1-4899-9665-7Published: 28 January 2015

  • eBook ISBN: 978-1-4614-5404-5Published: 09 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 268

  • Topics: Immunology, Antibodies, Medical Microbiology

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