TRIM/RBCC Proteins

1. Front Matter

   Pages i-xix

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2. Genomics and Evolution of the TRIM Gene Family

   • Germana Meroni

   Pages 1-9

3. The Tripartite Motif

   • Lucia Micale, Evelyne Chaignat, Carmela Fusco, Alexandre Reymond, Giuseppe Merla

   Pages 11-25

4. Trim Proteins as Ring Finger E3 Ubiquitin Ligases

   • Kazuhiro Ikeda, Satoshi Inoue

   Pages 27-37

5. PML Nuclear Bodies and Other Trim-Defined Subcellular Compartments

   • Elizabeth C. Batty, Kirsten Jensen, Paul S. Freemont

   Pages 39-58

6. TRIM Involvement in Transcriptional Regulation

   • Florence Cammas, Konstantin Khetchoumian, Pierre Chambon, Régine Losson

   Pages 59-76

7. TRIM Proteins in Cancer

   • Valeria Cambiaghi, Virginia Giuliani, Sara Lombardi, Cristiano Marinelli, Francesca Toffalorio, Pier Giuseppe Pelicci

   Pages 77-91

8. TRIM Proteins and the Innate Immune Response to Viruses

   • Melvyn W. Yap, Jonathan P. Stoye

   Pages 93-104

9. The Microtubule-Associated C-I Subfamily of TRIM Proteins and the Regulation of Polarized Cell Responses

   • Timothy C. Cox

   Pages 105-118

10. MuRFs Specialized Members of the TRIM/RBCC Family with Roles in the Regulation of the Trophic State of Muscle and Its Metabolism

    • Olga Mayans, Siegfried Labeit

    Pages 119-129

11. TRIM Proteins in Development

    • Francesca Petrera, Germana Meroni

    Pages 131-141

12. Back Matter

    Pages 143-145

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The genomic ‘golden age’ has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.

• Germana Meroni
• RBCC
• TRIM family members

• Cluster in Biomedicine, CBM S.c.r.l., Trieste, Italy

  Germana Meroni

Germana Meroni is a graduate of the University of Milan, Italy. She was a post‑graduate fellow at the Department of Biotechnology of the San Raffaele Hospital in Milan, Italy, and then post‑doctoral fellow at the Department of Human and Molecular Genetics of Baylor College of Medicine, Houston, TX (USA). She established her research group at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and then moved as leader of the Functional Genomics Laboratory at the Cluster in Biomedicine within AREA Science Park in Trieste, Italy. Her main research interest is the genetics and biochemistry of the Tripartite Motif family in health and disease.

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