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Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines

  • Book
  • © 2013

Overview

Editors:
  1. Manmohan Singh

    1. Novartis Vaccines Research, Cambridge, USA

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  • Focus on the future of vaccines
  • Addresss delivery systems for vaccines
  • Explore the use of nanoparticles in vaccine delivery?

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-x
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  2. Novel Immune Potentiators and Delivery Systems for Enhancing Vaccine Potency

    1. Front Matter

      Pages 1-1
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  3. Novel Immune Potentiators and delivery systems for enhancing vaccine potency

    1. TLR7/8 Agonists as Vaccine Adjuvants

      • Mark A. Tomai, John P. Vasilakos
      Pages 3-18

    2. Preclinical and Clinical Development of Synthetic iNKT-Cell Glycolipid Agonists as Vaccine Adjuvants

      • Josianne Nitcheu, Sandrine Crabe, Gwyn Davies, Vincent Serra
      Pages 19-64

    3. Mucosal Vaccination: Opportunities and Challenges

      • Olga Borges, Gerrit Borchard
      Pages 65-80

    4. Oral Vaccination: Attenuated and Gene-Based

      • Wendy Peters, Ciaran D. Scallan, Sean N. Tucker
      Pages 81-104

  4. Design and Development of Next Generation Vaccines

    1. Front Matter

      Pages 105-105
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  5. Design and Development of next generation vaccines

    1. Development of Biophysical Assays to Better Understand Adjuvanted Vaccine Formulation Potency and Stability

      • James Chesko, Thomas Vedvick, Steve Reed
      Pages 107-118

    2. High Throughput Screening for Stabilizers of Vaccine Antigens

      • C. Russell Middaugh, David B. Volkin, Sangeeta B. Joshi
      Pages 119-143

    3. Exploring Novel Analytical Tools to Improve Characterization of Vaccine Formulations

      • Michele Pallaoro
      Pages 145-159

    4. Immunobioengineering Approaches Towards Combinatorial Delivery of Immune-Modulators and Antigens

      • Ankur Singh, Pallab Pradhan, Krishnendu Roy
      Pages 161-181

  6. Novel Delivery Technologies for Vaccines

    1. Front Matter

      Pages 183-183
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  7. Novel Delivery Technologies for vaccines

    1. Current Status of Electroporation Technologies for Vaccine Delivery

      • Claire F. Evans, Drew Hannaman
      Pages 185-215

    2. Microneedles for Intradermal Vaccination: Immunopotentiation and Formulation Aspects

      • Alexander K. Andrianov
      Pages 217-232

    3. MicroCor® Transdermal Delivery System: A Safe, Efficient, and Convenient Transdermal System for Vaccine Administration

      • Parminder Singh, Guohua Chen, Wade Worsham
      Pages 233-244

    4. Mimopath™-Based Vaccine Delivery

      • Kees Leenhouts
      Pages 245-265

  8. Novel Particulate Delivery Systems for Vaccines and Adjuvants

    1. Front Matter

      Pages 267-267
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  9. Novel Particulate delivery systems for vaccines and adjuvants

    1. NanoBio™ Nanoemulsion for Mucosal Vaccine Delivery

      • Tarek Hamouda, Jakub Simon, Ali Fattom, James Baker
      Pages 269-286

    2. Influenza Virosomes as Antigen Delivery System

      • Christian Moser, Mario Amacker
      Pages 287-307

    3. Matrix M Adjuvant Technology

      • Karin Lövgren Bengtsson
      Pages 309-320
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Keywords

About this book

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Editors and Affiliations

  • Novartis Vaccines Research, Cambridge, USA

    Manmohan Singh

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