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Mucosal Immunology of Acute Bacterial Pneumonia

  • Book
  • © 2013

Overview

Editors:
  1. Alice Prince

    1. Columbia University, New York, USA

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  • Will address an area of immunology which has not received appropriate attention: The airway's response to bacterial pathogens.
  • Will discuss how innate immune signaling is orchestrated in response to specific common airway pathogens.
  • The book will act as a targeted, but comprehensive volume on the subject
  • Includes supplementary material: sn.pub/extras

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. Alveolar Macrophages

    • David H. Dockrell, Paul J. Collini, Helen M. Marriott
    Pages 1-48

  3. Lung Dendritic Cells and Pulmonary Defence Mechanisms to Bacteria

    • Bart N. Lambrecht, Katrijn Neyt, Corine H. GeurtsvanKessel, Hamida Hammad
    Pages 49-66

  4. CD4 T-Cell Immunity in the Lung

    • Jay K. Kolls
    Pages 67-82

  5. Neutrophils in Acute Bacterial Pneumonia

    • John C. Gomez, Qin Wang, Claire M. Doerschuk
    Pages 83-124

  6. Toll-Like Receptors in the Airway Epithelium

    • Shawn J. Skerrett
    Pages 125-138

  7. Type I Interferon Responses to Airway Pathogens

    • Dane Parker
    Pages 139-158

  8. Transcriptional Signaling Hubs in Epithelial Cells During Pneumonia

    • Lee J. Quinton, Joseph P. Mizgerd
    Pages 159-183

  9. Innate Immune Responses in Ventilator-Associated Pneumonia

    • Megan N. Ballinger, Theodore J. Standiford
    Pages 185-212

  10. Streptococcus pneumoniae: The Prototype of Lung Responses in Pneumonia

    • Jessica Humann, Kim LeMessurier, Elaine Tuomanen
    Pages 213-238

  11. Staphylococcus aureus Infection in the Respiratory Tract

    • Alice Prince
    Pages 239-258

  12. Pseudomonas aeruginosa and Mucosal Defenses in the Lung

    • Taylor S. Cohen
    Pages 259-269

  13. Back Matter

    Pages 271-277
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Keywords

About this book

In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens.  The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections.  It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae.   By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.

Editors and Affiliations

  • Columbia University, New York, USA

    Alice Prince

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