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Prions and Diseases

Volume 1, Physiology and Pathophysiology

  • Book
  • © 2013

Overview

Editors:
  1. Wen-Quan Zou

    1. , Department of Pathology, Case Western Reserve University School o, Cleveland, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Pierluigi Gambetti

    1. , Department of Neuropathology, Case Western Reserve University School o, Cleveland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Authored by a team of leading researchers and clinicians

  • Updated knowledge and concepts on pathogenic prion proteins and prion diseases

  • Present state-of the art findings and hypotheses beyond prions and prion diseases

  • Includes supplementary material: sn.pub/extras

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-ix
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  2. Transmissible Spongiform Encephalopathy: From its Beginnings to Daniel Carlton Gajdusek

    • Paul Brown
    Pages 1-19

  3. The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein

    • Glenn L. Millhauser
    Pages 21-34

  4. Role of Cellular Prion Protein in the Amyloid-β Oligomer Pathophysiology of Alzheimer’s Disease

    • Adam C. Kaufman, Stephen M. Strittmatter
    Pages 35-48

  5. Cellular Prion Protein and Cancers

    • Wei Xin, Man-sun Sy, Chaoyang Li
    Pages 49-66

  6. Insoluble Cellular Prion Protein

    • Wen-Quan Zou
    Pages 67-82

  7. Protein Misfolding Cyclic Amplification

    • Fabio Moda, Sandra Pritzkow, Claudio Soto
    Pages 83-92

  8. Cofactor Involvement in Prion Propagation

    • Surachai Supattapone, Michael B. Miller
    Pages 93-105

  9. Prion Protein Conversion and Lipids

    • Jiyan Ma
    Pages 107-119

  10. New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating

    • Ilia V. Baskakov
    Pages 121-133

  11. Infectious and Pathogenic Forms of PrP

    • Emiliano Biasini, David A. Harris
    Pages 135-146

  12. Cellular Mechanisms of Propagation and Clearance

    • Hermann M. Schatzl
    Pages 147-160

  13. Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains

    • Jiri G. Safar
    Pages 161-179

  14. Modeling the Cell Biology of Prions

    • Richard Rubenstein, Robert B. Petersen
    Pages 181-192

  15. Prion Strain Interference

    • Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz
    Pages 193-204

  16. Introduction to Yeast and Fungal Prions

    • Reed B. Wickner
    Pages 205-215

  17. Yeast Prions Are Pathogenic, In-Register Parallel Amyloids

    • Reed B. Wickner, Herman K. Edskes, David A. Bateman, Amy C. Kelly, Anton Gorkovskiy
    Pages 217-231

  18. Back Matter

    Pages 233-241
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Keywords

About this book

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

Editors and Affiliations

  • , Department of Pathology, Case Western Reserve University School o, Cleveland, USA

    Wen-Quan Zou

  • , Department of Neuropathology, Case Western Reserve University School o, Cleveland, USA

    Pierluigi Gambetti

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