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  • © 2013

Ten Years of Progress in GW/P Body Research

  • Provides a history of the discovery of cytoplasmic structures
  • Serves as a 10 year review of researchers' current knowledge in subcellular structures
  • This book appeals to cell biologists, investigators involved in microRNA and post-translational regulation of gene expression research, clinical scientiss, and industries that are now using knowledge of the miRNA pathway to design and develop new therapeutics for a broad range of conditions
  • Includes supplementary material: sn.pub/extras

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
  2. The Discovery of GW Bodies

    • Marvin J. Fritzler, Edward K. L. Chan
    Pages 5-21
  3. The Discovery and Analysis of P Bodies

    • Saumya Jain, Roy Parker
    Pages 23-43
  4. Autoantibodies to Argonaute 2 (Su Antigen)

    • Minoru Satoh, Jason Y. F. Chan, Angela Ceribelli, Monica Vazquez del-Mercado, Edward K. L. Chan
    Pages 45-59
  5. GW/P-Bodies and Autoimmune Disease

    • Donald B. Bloch, Rita A. Nobre, Wei-Hong Yang
    Pages 61-70
  6. Function of GW182 and GW Bodies in siRNA and miRNA Pathways

    • Bing Yao, Songqing Li, Edward K. L. Chan
    Pages 71-96
  7. Post-transcriptional Stimulation of Gene Expression by MicroRNAs

    • Sooncheol Lee, Shobha Vasudevan
    Pages 97-126
  8. Gawky (GW) is the Drosophila melanogaster GW182 Homologue

    • Jing Li, Tom C. Hobman, Andrew J. Simmonds
    Pages 127-145
  9. The Role of GW182 Proteins in miRNA-Mediated Gene Silencing

    • Joerg E. Braun, Eric Huntzinger, Elisa Izaurralde
    Pages 147-163
  10. Deadenylation and P-Bodies

    • Chyi-Ying A. Chen, Ann-Bin Shyu
    Pages 183-195
  11. Relationship of GW/P-Bodies with Stress Granules

    • Georg Stoecklin, Nancy Kedersha
    Pages 197-211
  12. Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research

    • Edward K. L. Chan, Bing Yao, Marvin J. Fritzler
    Pages 261-270
  13. Back Matter

    Pages 271-276

About this book

GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.

Editors and Affiliations

  • College of Dentistry, Department of Oral Biology, University of Florida, Gainesville, USA

    Edward K. L. Chan

  • Dept. Medicine & Medical Biochemistry, University of Calgary, Calgary, Canada

    Marvin J. Fritzler

Bibliographic Information

  • Book Title: Ten Years of Progress in GW/P Body Research

  • Editors: Edward K. L. Chan, Marvin J. Fritzler

  • DOI: https://doi.org/10.1007/978-1-4614-5107-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013

  • Hardcover ISBN: 978-1-4614-5106-8Published: 07 December 2012

  • Softcover ISBN: 978-1-4939-0251-4Published: 29 January 2015

  • eBook ISBN: 978-1-4614-5107-5Published: 09 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 276

  • Topics: Human Genetics, Cell Biology, Biochemistry, general

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access