Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

1. Front Matter

   Pages i-x

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2. Immunomic Discovery of Adjuvants, Delivery Systems, and Candidate Subunit Vaccines: A Brief Introduction

   • Darren R. Flower, Yvonne Perrie

   Pages 1-11

3. Bacterial Genomes and Vaccine Design

   • Valeria Cafardi, John L. Telford, Davide Serruto

   Pages 13-37

4. Identification of Candidate Vaccine Antigens In Silico

   • Darren R. Flower, Matthew N. Davies, Irini A. Doytchinova

   Pages 39-71

5. Post-genomic Antigen Discovery: Bioinformatical Approaches to Reveal Novel T Cell Antigens of Mycobacterium bovis

   • Martin Vordermeier, Gareth J. Jones, Samantha Sampson, Stephen V. Gordon

   Pages 73-90

6. Genome-Based Computational Vaccine Discovery by Reverse Vaccinology

   • Yongqun He

   Pages 91-104

7. Computational Prediction of Protein Subcellular Localization, Genomic Islands, and Virulence to Aid Antigen Discovery

   • Bhavjinder K. Dhillon, Nancy Y. Yu, Fiona S. L. Brinkman

   Pages 105-115

8. On the Development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge

   • Hifzur Rahman Ansari, Darren R. Flower, Gajendra P. S. Raghava

   Pages 117-130

9. What Have Dendritic Cells Ever Done for Adjuvant Design? Cellular and Molecular Methods for the Rational Development of Vaccine Adjuvants

   • Alexander D. Edwards

   Pages 131-154

10. Towards the Systematic Discovery of Immunomodulatory Adjuvants

    • Darren R. Flower

    Pages 155-180

11. Designing Liposomes as Vaccine Adjuvants

    • Malou Henriksen-Lacey, Yvonne Perrie

    Pages 181-203

12. Designing Nonionic Surfactant Vesicles for the Delivery of Antigens for Systemic and Alternative Delivery Routes

    • Jitinder Wilkhu, Anil Vangala, Afzal R. Mohammed, Yvonne Perrie

    Pages 205-232

13. Immune Stimulating Complexes (ISCOMs) and Quil-A Containing Particulate Formulations as Vaccine Delivery Systems

    • S. Hook, T. Rades

    Pages 233-261

14. Formulation and Characterisation of PLGA Microspheres as Vaccine Adjuvants

    • Daniel J. Kirby, Randip Kaur, Yvonne Perrie

    Pages 263-289

15. Powder Vaccines for Pulmonary Delivery

    • Tom Jin, Eric Tsao

    Pages 291-301

16. Back Matter

    Pages 305-314

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This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

• Adjuvants
• Antigens
• Immunomics
• Reverse Vaccinology
• vaccines

• Aston Pharmacy School, School of Life and Health Sciences, University of Aston, Birmingham, United Kingdom

  Darren R. Flower

• Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom

  Yvonne Perrie

Dr. Darren R Flower. An interdisciplinary scientist, with special interest in bioinformatics, computational chemistry, and cheminformatics, Dr. Flower has wide-ranging experience of the pre-clinical research environment in both academia and the pharmaceutical industry. Before joining Aston University as a Reader, Dr. Flower was a Jenner Research Fellow and Principal Investigator at the University of Oxford; and formerly a Senior Group Leader managing a large research group at The Edward Jenner Institute for Vaccine Research. Before that, Dr. Flower was a drug discovery scientist in the Pharmaceutical industry. Dr. Flower is a Fellow of the Royal Society of Chemistry, and the author of over 150 research papers and reviews, and 7 Books, including the monograph: Bioinformatics for Vaccinology.

Professor Yvonne Perrie is Pharmacist whose research focuses on the development on delivery systems for drugs and vaccines. Prof. Perrie is currently Head of Pharmacy and Chair in Drug Delivery within Aston University.  Prof. Perrie received her Ph.D. from the University of London, UK where she investigated the use of liposomes for gene delivery under the supervision of Professor Gregory Gregoriadis. Prof. Perrie then joined a newly established Drug Delivery Company, Lipoxen Technologies Ltd., prior to taking her post at Aston University. Prof. Perrie is currently Chair of the UK and Ireland Controlled Release Society and has approximately 100 research papers and reviews focusing on the research and development of drug delivery systems.

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