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  • © 2013

DNA Helicases and DNA Motor Proteins

Editors:

  • Provides first systematic overview of structure, function and regulation of DNA helicases
  • Integrates knowledge obtained through diverse technical approaches
  • Gives a unified view on how helicases function in the cell and are regulated in response to different cellular stresses

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 767)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
  2. Overview: What Are Helicases?

    • Colin G. Wu, Maria Spies
    Pages 1-16
  3. Structure and Mechanisms of SF1 DNA Helicases

    • Kevin D. Raney, Alicia K. Byrd, Suja Aarattuthodiyil
    Pages 17-46
  4. Structure and Mechanisms of SF2 DNA Helicases

    • David C. Beyer, Mohamed Karem Ghoneim, Maria Spies
    Pages 47-73
  5. Structure and Mechanism of Hexameric Helicases

    • Barbara Medagli, Silvia Onesti
    Pages 75-95
  6. Helicases at the Replication Fork

    • Peter McGlynn
    Pages 97-121
  7. DNA Helicases Associated with Genetic Instability, Cancer, and Aging

    • Avvaru N. Suhasini, Robert M. Brosh Jr.
    Pages 123-144
  8. RecQ Helicases: Conserved Guardians of Genomic Integrity

    • Nicolai Balle Larsen, Ian D. Hickson
    Pages 161-184
  9. Roles of DNA Helicases in the Mediation and Regulation of Homologous Recombination

    • James M. Daley, Hengyao Niu, Patrick Sung
    Pages 185-202
  10. DNA Helicases in NER, BER, and MMR

    • Jochen Kuper, Caroline Kisker
    Pages 203-224
  11. The FtsK Family of DNA Pumps

    • Gaëlle Demarre, Elisa Galli, François-Xavier Barre
    Pages 245-262
  12. ATP-Dependent Chromatin Remodeling

    • Jaya Yodh
    Pages 263-295
  13. Erratum to: Structure and Mechanisms of SF1 DNA Helicases

    • Kevin D. Raney, Alicia K. Byrd, Suja Aarattuthodiyil
    Pages E1-E1
  14. Back Matter

    Pages 297-299

About this book

In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines.

The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Editors and Affiliations

  • , Department of Biochemistry, University of Iowa Carver College of Med, Iowa City, USA

    Maria Spies

Bibliographic Information

  • Book Title: DNA Helicases and DNA Motor Proteins

  • Editors: Maria Spies

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-5037-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013

  • Hardcover ISBN: 978-1-4614-5036-8Published: 17 November 2012

  • Softcover ISBN: 978-1-4899-9851-4Published: 23 December 2014

  • eBook ISBN: 978-1-4614-5037-5Published: 19 November 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XII, 299

  • Number of Illustrations: 11 b/w illustrations, 58 illustrations in colour

  • Topics: Human Genetics, Biochemistry, general, Cell Biology, Biomedicine, general

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access