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  • © 2013

Systems Biology of Tuberculosis

  • Provides a detailed account of the systems biology of tuberculosis
  • This book describes how systems biology can be applied to the control of tuberculosis, including the development of new treatments
  • Readers are given an account of how systems biology is providing insights into tuberculosis

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xv
  2. Modeling Mycobacterium tuberculosis H37Rv In Silico

    • Neema Jamshidi, Aarash Bordbar, Bernhard Palsson
    Pages 1-19
  3. Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis

    • Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano, Anshu Bhardwaj, Vinod Scaria et al.
    Pages 21-35
  4. Probing Gene Regulatory Networks to Decipher Host–Pathogen Interactions

    • Kanury V. S. Rao, Dhiraj Kumar, Shekhar C. Mande
    Pages 37-54
  5. Metabolism of Mycobacterium tuberculosis

    • Dany J. V. Beste, Johnjoe McFadden
    Pages 55-78
  6. Host–Pathogen Interactions

    • Simon J. Waddell, Axel von Kamp, Steffen Klamt, Olivier Neyrolles
    Pages 107-126
  7. A Systems Biology Approach for Understanding Granuloma Formation and Function in Tuberculosis

    • Mohammad Fallahi-Sichani, Simeone Marino, JoAnne L. Flynn, Jennifer J. Linderman, Denise E. Kirschner
    Pages 127-155
  8. Stochastic Gene Expression in Bacterial Pathogens: A Mechanism for Persistence?

    • Andrea Rocco, Andrzej Kierzek, Johnjoe McFadden
    Pages 157-177
  9. Drug Discovery

    • Nagasuma Chandra
    Pages 179-192
  10. Immunological Biomarkers for Tuberculosis: Potential for a Combinatorial Approach

    • Richard Pine, Yuri Bushkin, Maria Laura Gennaro
    Pages 193-219
  11. Back Matter

    Pages 221-226

About this book

The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.

Editors and Affiliations

  • Microbial and Cellular Sciences, University of Surrey, Guildford, United Kingdom

    Johnjoe McFadden

  • School of Biomedical and Molecular Scien, University of Surrey, Guildford, United Kingdom

    Dany J.V. Beste

  • Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

    Andrzej M. Kierzek

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access