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Role of the Transcriptome in Breast Cancer Prevention

  • Book
  • © 2013

Overview

Authors:
  1. Jose Russo

    1. Fox Chase Cancer Center, Philadelphia, USA

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  2. Irma H. Russo

    1. Fox Chase Cancer Center, Philadelphia, USA

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  • Provides new insight on cancer prevention based on meticulously researched processed that have been gleaned from basic to translational research with a direct clinical application

  • Targeted to the medical profession and those interested in biomedical research

  • Outlines a model to the basic researchers and for those that are aiming to apply their work in the future to the clinic

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
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  2. The Epidemiology of Breast Cancer and the Basis for Prevention

    • Jose Russo, Irma H. Russo
    Pages 1-27

  3. An In Vivo Model of Breast Cancer Prevention

    • Jose Russo, Irma H. Russo
    Pages 29-71

  4. Comparative Effects of the Preventive Effect of Pregnancy, Steroidal Hormones, and hCG in the Transcriptomic Profile of the Rat Mammary Gland

    • Jose Russo, Irma H. Russo
    Pages 73-189

  5. The Use of In Vitro Three-Dimensional System for Studying Breast Cancer and Preventing Agents

    • Jose Russo, Irma H. Russo
    Pages 191-241

  6. Methodological Approach for Studying the Human Breast

    • Jose Russo, Irma H. Russo
    Pages 243-268

  7. The Transcriptome of Breast Cancer Prevention

    • Jose Russo, Irma H. Russo
    Pages 269-308

  8. Chromatin Remodeling and Pregnancy-Induced Differentiation

    • Jose Russo, Irma H. Russo
    Pages 309-335

  9. The Role of Spliceosome in the Human Breast

    • Jose Russo, Irma H. Russo
    Pages 337-390

  10. Noncoding RNAs and Breast Cancer Prevention

    • Jose Russo, Irma H. Russo
    Pages 391-407

  11. The Role of Stem Cell in Breast Cancer Prevention

    • Jose Russo, Irma H. Russo
    Pages 409-439

  12. Back Matter

    Pages 441-453
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Keywords

About this book

This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data.

Authors and Affiliations

  • Fox Chase Cancer Center, Philadelphia, USA

    Jose Russo, Irma H. Russo

Bibliographic Information

  • Book Title: Role of the Transcriptome in Breast Cancer Prevention

  • Authors: Jose Russo, Irma H. Russo

  • DOI: https://doi.org/10.1007/978-1-4614-4884-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-4883-9Published: 07 November 2012

  • Softcover ISBN: 978-1-4899-8993-2Published: 13 December 2014

  • eBook ISBN: 978-1-4614-4884-6Published: 07 November 2012

  • Edition Number: 1

  • Number of Pages: XIV, 454

  • Topics: Cancer Research, Pharmacology/Toxicology

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