Overview
- Based on the 6th International Conference on Sodium Calcium Exchange
- Includes information from internationally-known experts on sodium calcium exchange
- Incorporates recent advances in research
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 961)
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Table of contents (38 papers)
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Front Matter
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Historical Perspective
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Front Matter
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Structural and Functional Aspects of NCX
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Front Matter
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Structural and Functional Aspects of NCKX
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Front Matter
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Genetic and Epigenetic Regulation
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Front Matter
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Regulatory Mechanisms of NCX
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Front Matter
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About this book
This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011.
The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.
The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.
Reviews
From the reviews:
“It collects in one place state-of-the-art information on all facets of the structure and function of sodium calcium exchangers in biological systems with a special focus on pathophysiological implications. … This will be of most value to research scientists, including students, whose research involves studying the mechanisms for maintaining ion homeostasis in biological systems. … I highly recommend it to all researchers who work in the field of ion homeostasis.” (Thomas L. Pazdernik, Doody's Book Reviews, March, 2013)Editors and Affiliations
About the editor
Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the “Federico II” University of Naples, Italy. He is coordinator of the University’s Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases.
Bibliographic Information
Book Title: Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications
Book Subtitle: Proceedings of the 6th International Conference on Sodium Calcium Exchange
Editors: Lucio Annunziato
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4614-4756-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013
Hardcover ISBN: 978-1-4614-4755-9Published: 08 December 2012
Softcover ISBN: 978-1-4899-7821-9Published: 23 August 2016
eBook ISBN: 978-1-4614-4756-6Published: 09 December 2012
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XXIV, 463
Topics: Neurosciences, Immunology, Cardiology, Endocrinology