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Natural Products and Cancer Drug Discovery

  • Book
  • © 2013

Overview

Editors:
  1. Frank E. Koehn

    1. , Natural Products/World Wide Medicinal Ch, Pfizer Inc, Groton, USA

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  • Features up-to-date research
  • Provides a broad overview of natural products as they relate to cancer chemotherapy
  • Explores new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xii
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  2. Natural Product Drugs and Cancer Therapeutics

    1. Front Matter

      Pages 1-1
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    2. The Impact of Natural Products Upon Cancer Chemotherapy

      • A. Ganesan
      Pages 3-15

    3. Identification and Development of Vascular Disrupting Agents: Natural Products That Interfere with Tumor Growth

      • Andrea T. Hooper, Frank Loganzo, Chad May, Hans-Peter Gerber
      Pages 17-38

    4. Discodermolide: Past, Present, and Future

      • Ross E. Longley
      Pages 39-58

    5. HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents

      • Lilibeth A. Salvador, Hendrik Luesch
      Pages 59-95

    6. Natural Product Cytotoxins as Payloads for Antibody Drug Conjugates

      • Frank E. Koehn
      Pages 97-119

  3. Advances in Natural Product Cancer Drug Discovery

    1. Front Matter

      Pages 121-121
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    2. Natural Product Scaffolds in Cancer Therapy

      • Christian P. Mang, Lars Ole Haustedt
      Pages 123-173

    3. The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery

      • Claudia Eva-Maria Unsin, Scott R. Rajski, Ben Shen
      Pages 175-191

    4. Accessing Anti-cancer Natural Products by Plant Cell Culture

      • Lisa M. Leone, Susan C. Roberts
      Pages 193-211

    5. Natural Products as Tools for Discovering New Cancer Targets

      • John A. Beutler
      Pages 213-237

  4. Back Matter

    Pages 239-244
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Keywords

About this book

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Reviews

From the reviews:

“This book covers a range of topics related to drug discovery, natural product chemistry, cancer biology, and chemical biology. … value to researchers in both academia and the pharmaceutical industry who are involved in the study and development of natural products as potential chemotherapeutic agents. It also will be helpful to basic biomedical scientists and clinicians as a quick overview of this area of research and its recent developments. … also provides a critical assessment of the challenges that researchers in this research field face.” (Bao Ting Zhu, Doody’s Review Service, March, 2013)

Editors and Affiliations

  • , Natural Products/World Wide Medicinal Ch, Pfizer Inc, Groton, USA

    Frank E. Koehn

Bibliographic Information

  • Book Title: Natural Products and Cancer Drug Discovery

  • Editors: Frank E. Koehn

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4614-4654-5

  • Publisher: Humana New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-4653-8Published: 10 November 2012

  • Softcover ISBN: 978-1-4899-9565-0Published: 13 December 2014

  • eBook ISBN: 978-1-4614-4654-5Published: 09 November 2012

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XII, 244

  • Topics: Cancer Research, Oncology, Pharmacology/Toxicology

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