Pharmacology of Hormonal Polypeptides and Proteins

1. Front Matter

   Pages i-xi

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2. Peptide and Protein Chemistry

   1. Some New Methods in Peptide Synthesis

      • Iphigenia Photaki

      Pages 1-10

   2. Novel Techniques in Peptide Synthesis

      • A. Patchornik

      Pages 11-16

   3. Synthetic polypeptides with enhanced biological activities

      • R. A. Boissonnas

      Pages 17-17

   4. Synthesis of Gastrointestinal Hormones

      • Miguel A. Ondetti, John T. Sheehan, M. Bodanszky

      Pages 18-31

   5. The Synthesis of Caerulein

      • L. Bernardi, G. Bosisio, R. de Castiglione, O. Goffredo

      Pages 32-34

   6. Techniques for the Synthesis of Acth And Msh Peptides and Analogues

      • W. Rittel

      Pages 35-47

   7. Studies with Tryptophan in Solid-Phase Synthesis

      • Garland R. Marshall

      Pages 48-52

3. Posterior Pituitary Hormones

   1. Oxytocin — Molecular Aspects

      • B. Berde

      Pages 53-65

   2. Oxytocin and Vasopressin: Biochemical Considerations

      • J. Rudinger, V. Pliška, I. Rychlík, F. Šorm

      Pages 66-72

   3. Neurophysin, Oxytocin and Vasopressin in Neurosecretory Granules and in Crystalline Complexes

      • D. B. Hope

      Pages 73-83

   4. Mechanism of Release and Mechanism of Action of Vasopressin

      • Niels A. Thorn

      Pages 84-92

   5. Radioimmunoassay of Oxytocin

      • Seymour M. Glick, Mary Wheeler, Avir Kagan, Perianna Kumaresan

      Pages 93-100

   6. Comparison of the Pharmacological Properties of Two Highly Potent, Crystalline Neurohypophyseal Hormone Analogs: Deamino-1-Seleno-Oxytocin and Deamino-Oxytocin

      • Roderich Walter, Irving L. Schwartz

      Pages 101-104

4. Hypothalamic Neurohumoral Principles

   1. Structure and Function of Pituitary Grafts, Related to the Problem of Hypothalamic Control of Hypophyseal Activity

      • L. Desclin, J. Flament-Durand

      Pages 105-111

   2. The Physiology and Biochemistry of Luteinizing Hormone-Releasing Factor and Follicle Stimulating Hormone-Releasing Factor

      • S. M. McCann, S. Watanabe, D. B. Crighton, D. Beddow, A. P. S. Dhariwal

      Pages 112-122

   3. Studies on the Isolation of Luteinizing Hormone Releasing Factor (LRF)

      • H. Gregory, A. L. Walpole, H. M. Charlton, G. W. Harris, May Reed

      Pages 123-127

   4. Studies on Luteinizing Hormone Releasing Factor (LRF) in Hypophysial Portal Blood of Rats

      • G. Fink

      Pages 128-137

   5. Studies on the Mechanism of Action of Hypothalamic FSH- and LH-Releasing Factors

      • M. Jutisz, A. Berault, M. P. de la Llosa

      Pages 138-147

   6. Thyrotropin-Releasing Factor (TRF) of Hypothalamic Origin. A Review of Physiological and Biochemical Studies

      • Roger Guillemin

      Pages 148-157

It can be concluded (under the specific experimental procedures em­ ployed) that:- 1) HCG labelled with 1 - 2 atoms of radioactive iodine did not differ sig­ nificantly from the unlabelled hormone; 2) The ovary alone exhibited a capacity to affix specifically HCG; 3) The amount of radioactive material in the ovary was directly proport­ ional to the quantity of labelled HCG injected; 4) When the HCG present in the circulation is bound to an antiserum to HCG, the antigen-antibody complex is not concentrated by the ovary; 5) Circulating labelled HCG decreased to 50% within 30 minutes following a single intravenous injection; 6) There are four different phases of ovarian uptake of HCG, namely:­ the first phase, when there is only an inflow from the circulation and stor­ age mainly in the follicular envelopes; the second phase, when there is a greater inflow than outflow; the third phase, when the inflow is equal to the outflow; and the fourth period, when the outflow is bigger than the in­ flow. REFERENCES 1. Lunenfeld, B. and Eshkol, A. Vitamins and Hormones (1967) 25:165 2. Eshkol, A. In: Recent Research on Gonadotropbio Hormones, eds. E. T. Bell andJ. A. Loraine, Edinburgh, Livingstone (1967), p. 202. 3. Eshkol, A. and Lunenfeld, B. Proc. Tel-Hashomer Hosp. (1967) 6:4. ACKNOWLEOOMEN'IS This work was supported in part by a grant from the Population Council, N. Y. , U. S. A. andbyGrantNo.

• antibody
• antigen
• pharmacology
• protein
• research

• Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, USA

  Nathan Back

• Institute of Pharmacology, University of Milan, Milan, Italy

  Luciano Martini

• Institute of Pharmacology, University of Cagliari, Cagliari, Italy

  Rodolfo Paoletti

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