Authors:
- Reviews signaling pathways in the regulation of circulatory and respiratory function
- Describes ion and molecular carriers and receptors
- Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
Part of the book series: Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems (BBMCVS, volume 4)
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (12 chapters)
-
Front Matter
-
Back Matter
About this book
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.
Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.
Keywords
- blood flow behavior
- blood flow prediction
- cardiovascular systems modeling
- cell signalling pathways
- ion and molecule carriers described
- modeling respiratory function
- modeling simulation of flows
- physiological flows
- receptors ligands
- signaling mediators explained
- ventilatory systems modeling
- Systems Biology
Authors and Affiliations
-
Laboratoire Jacques-Louis Lions, Institut Universitaire de France, Université Pierre et Marie Curie, Paris, France
Marc Thiriet
Bibliographic Information
Book Title: Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems
Authors: Marc Thiriet
Series Title: Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems
DOI: https://doi.org/10.1007/978-1-4614-4370-4
Publisher: Springer New York, NY
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-4614-4369-8Published: 26 September 2012
Softcover ISBN: 978-1-4939-5207-6Published: 23 August 2016
eBook ISBN: 978-1-4614-4370-4Published: 25 September 2012
Series ISSN: 2193-1682
Series E-ISSN: 2193-1690
Edition Number: 1
Number of Pages: XV, 1064
Topics: Biological and Medical Physics, Biophysics, Biomedical Engineering and Bioengineering, Mathematical and Computational Biology, Systems Biology, Engineering Fluid Dynamics, Cardiology