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LC-MS in Drug Bioanalysis

  • Book
  • © 2012

Overview

Editors:
  1. Q. Alan Xu

    1. , Department of Experimental Therapeutics, University of Texas MD Anderson Cancer C, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Timothy L. Madden

    1. , Department of Experimental Therapeutics, University of Texas MD Anderson Cancer C, Houston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First book to discuss the development and validation of LC-MS methods and their applications in analyzing a wide range of drugs
  • Will facilitate pharmacologists, toxicologists, and physicians finding relevant analytical techniques in their clinical research
  • No other title in the subject area deals with so many methodological chapters

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
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  2. Internal Standards for Quantitative LC-MS Bioanalysis

    • Aimin Tan, Nadine Boudreau, Ann Lévesque
    Pages 1-32

  3. Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS

    • Min Meng, Patrick K. Bennett
    Pages 33-66

  4. Impact of Sampling Paper/Cards on Bioanalytical Quantitation via Dried Blood Spots by Liquid Chromatography-Mass Spectrometry

    • Jun Zhang, Ramona Rodila, Huaiqin Wu, Tawakol A. El-Shourbagy
    Pages 67-80

  5. Highly Sensitive Pharmaceutical and Clinical Analysis Using Selective Solid-Phase Extraction Coupled to Microflow Liquid Chromatography and Isotope-Dilution Mass Spectrometry

    • Haoying Yu, Xiaotao Duan, Jun Qu
    Pages 81-107

  6. Pitfalls of LC-MS/MS in the Clinical Laboratory

    • Christoph Seger, Michael Vogeser
    Pages 109-126

  7. Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics

    • Alan H. B. Wu, Kara L. Lynch
    Pages 127-141

  8. Liquid Chromatography-Mass Spectrometry for the Determination of Antidepressants and Some of their Major Metabolites in Human Biological Matrices

    • Ana de Castro, Angelines Cruz, Manuel López-Rivadulla
    Pages 143-175

  9. The Analysis of Antipsychotic Drugs in Human Biosamples by LC-MS

    • Eva Saar, Dimitri Gerostamoulos, Olaf H. Drummer, Jochen Beyer
    Pages 177-195

  10. Therapeutic Drug Monitoring of Targeted Anticancer Therapy. Tyrosine Kinase Inhibitors and Selective Estrogen Receptor Modulators: A Clinical Pharmacology Laboratory Perspective

    • Laurent Decosterd, Elyes Dahmane, Marine Neeman, Thierry Buclin, Chantal Csajka, Amina Haouala et al.
    Pages 197-250

  11. Applications of Mass Spectrometry in Analyses of Steroid Hormones

    • Zimeng Yan, Chang Cheng, Shaorong Liu
    Pages 251-286

  12. Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications

    • Harald John
    Pages 287-347

  13. Analysis of Illicit Drugs in Human Biological Samples by LC-MSn

    • Manuel Sergi, Sabino Napoletano
    Pages 349-398

  14. Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs

    • Jihai Pang, Timothy L. Madden
    Pages 399-422

  15. A Planar Integrated Micro-mass Spectrometer

    • Jörg Müller, Grigoriy Quiring, Maria Reinhardt-Szyba, Régulo Miguel Ramírez Wong, Henning Wehrs
    Pages 423-465

  16. Back Matter

    Pages 467-469
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Keywords

About this book

Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.

Editors and Affiliations

  • , Department of Experimental Therapeutics, University of Texas MD Anderson Cancer C, Houston, USA

    Q. Alan Xu, Timothy L. Madden

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