Overview
- Details experimental methods used to identify IDP's and to analyze thier stucture
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 896)
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Table of contents (30 protocols)
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SINGLE MOLECULE TECHNIQUES
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METHODS TO ASSESS PROTEIN SIZE AND SHAPE
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METHODS TO ANALYZE CONFORMATIONAL BEHAVIOR
Keywords
About this book
Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 2 includes sections on single molecule techniques, methods to assess protein size and shape, analyzing conformational behavior, mass-spectrometry, expression and purification of IDP’s. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Thorough and intuitive, Intrinsically Disordered Protein Analysis: Methods and Experimental Tools helps scientists further their investigations of these fascinating and dynamic molecules.
Editors and Affiliations
Bibliographic Information
Book Title: Intrinsically Disordered Protein Analysis
Book Subtitle: Volume 2, Methods and Experimental Tools
Editors: Vladimir N. Uversky, A. Keith Dunker
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4614-3704-8
Publisher: Springer New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2012
Hardcover ISBN: 978-1-4614-3703-1Published: 21 July 2012
Softcover ISBN: 978-1-4939-4484-2Published: 23 August 2016
eBook ISBN: 978-1-4614-3704-8Published: 23 July 2012
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIV, 454
Topics: Protein Science, Protein Structure