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Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication

  • Book
  • © 2013

Overview

Editors:
  1. Huang-Ge Zhang

    1. , James Brown Cancer Center, University of Louisville, Louisville, USA

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  • Explores recent findings on vesicle-based information transfer by exosomes

  • Provides an overview of exosomes biology and function

  • Discusses the role of exosomal tetraspanins in tumor progression

  • Includes supplementary material: sn.pub/extras

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Table of contents (10 chapters)

  1. Front Matter

    Pages 1-1
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  2. The Cell Biology of Exosomes: Historical and Perspectives

    • Alessandra Lo Cicero, Graça Raposo
    Pages 1-32

  3. The Role of Exosomal Shuttle RNA (esRNA) in Cell-to-Cell Communication

    • Cecilia Lässer, Maria Eldh, Jan Lötvall
    Pages 33-45

  4. Exosomal Lipids in Cell–Cell Communication

    • Michel Record
    Pages 47-68

  5. The Functional Importance of Tetraspanins in Exosomes

    • Sanyukta Rana, Margot Zöller
    Pages 69-106

  6. The Effects of Exosomes and Related Vesicles on Cancer Development, Progression, and Dissemination

    • William E. Grizzle, Huang-Ge Zhang
    Pages 107-129

  7. Circulating Cell-derived Vesicles Mediate Tumor Progression

    • Douglas D. Taylor, Gercel-Taylor Cicek
    Pages 131-148

  8. Immune Modulation of T Cells and Natural Killer Cells by Tumor-Derived Exosomes

    • Theresa L Whiteside
    Pages 149-168

  9. The Role of Tumor Exosomes in Tumorigenicity

    • Huang-Ge Zhang, Johan K. O. Skog
    Pages 169-179

  10. Microenvironmental Regulation of Metastasis by Exosomes

    • Haiying Zhang, Guillermo Garcia-Santos, Héctor Peinado, David C. Lyden
    Pages 181-201

  11. Microvesicles and Their Emerging Role in Cellular Therapies for Organ and Tissue Regeneration

    • Mariusz Z. Ratajczak, Kasia Mierzejewska, Magda Kucia, Nick Greco, Janina Ratajczak
    Pages 203-216

  12. Back Matter

    Pages 214-214
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Keywords

About this book

In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.

Editors and Affiliations

  • , James Brown Cancer Center, University of Louisville, Louisville, USA

    Huang-Ge Zhang

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