Authors:
- Written by a pioneer of the specialized field of neuroimmunology
- Presents a full overview of the neuroimmune system
- Useful to academics, researchers, and PhD students in neuroscience and neurobiology
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 6)
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Table of contents (12 chapters)
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Front Matter
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Back Matter
About this book
Proline-rich polypeptides - in particular (PRP-1) galarmin and its structural analogues – are, when isolated from the neurosecretory granules of neurohypophysis of humans and animals, a new type of hypothalamic peptides. They work against aerobic, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and do not have etiotropic properties. They are unique and capable substitutes to antibiotics, and, moreover, may be effective against strains, such as MRSA, that develop resistance to antibiotics. Galarmin, a component of the brain neuroendocrine system produced by the neurosecretory cells of hypothalamus, possesses immunomodulative, neuroprotective, antioxidant, antitumorigenic and hematopoietic properties. Moreover, galarmin and its structural analogues are powerful anti-inflammatory compounds.
In addition to presenting a full overview of the neuroimmune system, it emphasizes the antibacterial, neuroprotective, and neuroregenerative properties of proline-rich polypeptides. It investigates the mechanism of galarmin’s action during different infectious processes, where it targets such dangerous pathogens as Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methycillin resistant Staphylococcus aureus. This research is important from both a theoretical and a clinical point of view, creating new prospects for the modern pharmaceutical industry and neuroendocrine, neuroimmunological sciences.
Dr. Galoyan is a pioneer of the specialized field of neuroimmunology. During his 45-year long career, he has discovered a neuroendocrine immune system of the brain and identified a new type of brain cytokines: proline-rich polypeptides. The most important of these, PRP-1 (galarmin) has been shown to possess antibacterial properties and protect from certain neurotoxins.
Authors and Affiliations
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Inst. Biochemistry, Armenian Academy of Sciences, Yerevan, Armenia
Armen A. Galoyan
Bibliographic Information
Book Title: Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections
Authors: Armen A. Galoyan
Series Title: Advances in Neurobiology
DOI: https://doi.org/10.1007/978-1-4614-3667-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2012
Hardcover ISBN: 978-1-4614-3666-9Published: 06 June 2012
Softcover ISBN: 978-1-4899-8815-7Published: 17 July 2014
eBook ISBN: 978-1-4614-3667-6Published: 06 June 2012
Series ISSN: 2190-5215
Series E-ISSN: 2190-5223
Edition Number: 1
Number of Pages: XVI, 200
Topics: Neurosciences, Neurobiology, Immunology