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Mitochondrial Oxidative Phosphorylation

Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

  • Book
  • © 2012

Overview

Editors:
  1. Bernhard Kadenbach

    1. Philipps-Universitaet Marburg, Marburg, Germany

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  • Describes the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation
  • New approaches to study mitochondrial genetics, function, and disease
  • Examines the structure and function of complex I and complex III
  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction to Mitochondrial Oxidative Phosphorylation

    • Bernhard Kadenbach
    Pages 1-11

  3. Mitochondrial Dynamics: The Intersection of Form and Function

    • Andrew Ferree, Orian Shirihai
    Pages 13-40

  4. Biogenesis of Mitochondrial Proteins

    • Johannes M. Herrmann, Sebastian Longen, Daniel Weckbecker, Matthieu Depuydt
    Pages 41-64

  5. Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology

    • Daniele Ghezzi, Massimo Zeviani
    Pages 65-106

  6. Supramolecular Organisation of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation

    • Giorgio Lenaz, Maria Luisa Genova
    Pages 107-144

  7. Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain

    • Stefan Dröse, Ulrich Brandt
    Pages 145-169

  8. Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins

    • Richard K. Porter
    Pages 171-184

  9. Evolution of the Couple Cytochrome c and Cytochrome c Oxidase in Primates

    • Denis Pierron, Derek E. Wildman, Maik Hüttemann, Thierry Letellier, Lawrence I. Grossman
    Pages 185-213

  10. Reaction Mechanism of Mammalian Mitochondrial Cytochrome c Oxidase

    • Shinya Yoshikawa, Kazumasa Muramoto, Kyoko Shinzawa-Itoh
    Pages 215-236

  11. Phosphorylation of Mammalian Cytochrome c and Cytochrome c Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease

    • Maik Hüttemann, Icksoo Lee, Lawrence I. Grossman, Jeffrey W. Doan, Thomas H. Sanderson
    Pages 237-264

  12. Individual Biochemical Behaviour Versus Biological Robustness: Spotlight on the Regulation of Cytochrome c Oxidase

    • Rabia Ramzan, Petra Weber, Bernhard Kadenbach, Sebastian Vogt
    Pages 265-281

  13. Bigenomic Regulation of Cytochrome c Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism

    • Margaret T. T. Wong-Riley
    Pages 283-304

  14. Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection

    • Susanne Arnold
    Pages 305-339

  15. The Many Clinical Faces of Cytochrome c Oxidase Deficiency

    • Salvatore DiMauro, Kurenai Tanji, Eric A. Schon
    Pages 341-357

  16. Back Matter

    Pages 359-372
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Keywords

About this book

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.

Editors and Affiliations

  • Philipps-Universitaet Marburg, Marburg, Germany

    Bernhard Kadenbach

Bibliographic Information

  • Book Title: Mitochondrial Oxidative Phosphorylation

  • Book Subtitle: Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

  • Editors: Bernhard Kadenbach

  • DOI: https://doi.org/10.1007/978-1-4614-3573-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-3572-3Published: 24 June 2012

  • Softcover ISBN: 978-1-4939-0156-2Published: 18 July 2014

  • eBook ISBN: 978-1-4614-3573-0Published: 23 June 2012

  • Edition Number: 1

  • Number of Pages: XII, 372

  • Topics: Human Genetics, Gene Expression, Cell Biology

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