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  • Book
  • © 2012

RAMPs

  • Source of basic studies that range from biochemistry to molecular biology to receptor pharmacology and physiology
  • Written by authors well known in the RAMPs field
  • Provides information for scientists at different stages of their career including graduate students, post-doctoral fellows and senior scientists who are new to the RAMPs field

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 744)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xvii
  2. Introduction to Ramps

    • Narayanan Parameswaran, William S. Spielman
    Pages 1-11
  3. RAMPs and CGRP Receptors

    • James Barwell, Denise Wootten, John Simms, Debbie L. Hay, David R. Poyner
    Pages 13-24
  4. Regulation of GPCR Trafficking by RAMPs

    • Jennifer M. Bomberger, Narayanan Parameswaran, William S. Spielman
    Pages 25-37
  5. Regulation of Calcium Sensing Receptor Trafficking by RAMPs

    • Tristan Bouschet, Stéphane Martin, Jeremy M. Henley
    Pages 39-48
  6. Understanding RAMPs Through Genetically Engineered Mouse Models

    • Mahita Kadmiel, Kimberly L. Fritz-Six, Kathleen M. Caron
    Pages 49-60
  7. RAMPs as Drug Targets

    • Patrick M. Sexton, David R. Poyner, John Simms, Arthur Christopoulos, Debbie L. Hay
    Pages 61-74
  8. Ramp Like Proteins

    • Joel Mainland, Hiroaki Matsunami
    Pages 75-86
  9. Regulation of RAMP Expression in Diseases

    • Asha Jacob, Rongqian Wu, Ping Wang
    Pages 87-103
  10. Perspectives on Some Recent Studies on RAMPs

    • Narayanan Parameswaran, William S. Spielman
    Pages 105-112
  11. Back Matter

    Pages 113-114

About this book

 Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years.

Editors and Affiliations

  • Department of Physiology, Michigan State University, East Lansing, USA

    William S. Spielman, Narayanan Parameswaran

About the editors

William S. Spielman is a Professor of Physiology and former Chairperson of the Department of Physiology, Michigan State University, East Lansing, Michigan, USA. His research interests include receptor biology and signal transduction and renal physiology. He is a member of many national and international scientific societies including the American Physiological Society. Spielman earned the BS degree in Biology from Westminister College and the PhD degree in Physiology from the University of Missouri.

Narayanan Parameswaran is an Associate Professor in the Department of Physiology and Division of Pathology at Michigan State University, East Lansing, Michigan, USA. His main research interests include receptor biology, cell signaling, inflammation and inflammatory diseases. He is a member of the American Association of Immunology, Society of Leukocyte Biology and the Shock Society. Parameswaran received the Veterinary Medicine degree from Madras Veterinary College (India), the Master’s degree in Veterinary Physiology and Pharmacology from the Ohio State University and the Doctor of Philosophy degree in Physiology from the Michigan State University.

Bibliographic Information

  • Book Title: RAMPs

  • Editors: William S. Spielman, Narayanan Parameswaran

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-2364-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-2363-8Published: 14 February 2012

  • Softcover ISBN: 978-1-4939-5292-2Published: 23 August 2016

  • eBook ISBN: 978-1-4614-2364-5Published: 21 March 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVII, 114

  • Topics: Biomedicine general, Cell Biology, Molecular Medicine

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access