Editors:
- First book on this topic
- Authorship from many of the major players in the field of MS and myelin repair
- Of equal interest to academic clinical neurologists and neuroscientists
- Includes supplementary material: sn.pub/extras
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (11 chapters)
-
Front Matter
-
Back Matter
About this book
Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier.
Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients.
Reviews
From the book reviews:
“The textbook discusses the cellular and molecular mediators of demyelination and regeneration of myelin support. It does a credible and well evidenced job at these two goals. National and international experts contribute to the dialogue. … I recommend this book to neurologists, neuroscientists, neurosurgeons … .” (Joseph J. Grenier, Amazon.com, August, 2014)
Editors and Affiliations
-
School Veterinary Medicine, Dept. Medical Sciences, University of Wisconsin Madison, Madison, USA
Ian D. Duncan
-
Wellcome Trust and MRC Cambridge Stem Ce, and Department of Veterinary Medicine, University Cambridge, Cambridge, United Kingdom
Robin J M Franklin
Bibliographic Information
Book Title: Myelin Repair and Neuroprotection in Multiple Sclerosis
Editors: Ian D. Duncan, Robin J M Franklin
DOI: https://doi.org/10.1007/978-1-4614-2218-1
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-4614-2217-4Published: 31 August 2012
Softcover ISBN: 978-1-4899-8840-9Published: 19 September 2014
eBook ISBN: 978-1-4614-2218-1Published: 31 August 2012
Edition Number: 1
Number of Pages: XIV, 290
Topics: Neurosciences, Neurology, Neuroradiology, Neurobiology