Stem Cell Transplantation

1. Front Matter

   Pages i-xxv

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2. Basic Aspects of Transplantation

   1. The Frontiers of Organ Transplantation and Cell Therapy

      • Rafael Matesanz

      Pages 1-12

   2. Organ Transplantation in the 21th Century

      • Francisco Ortega

      Pages 13-26

   3. Imunology and the Challenge of Transplantation

      • Rebeca Alonso Arias, Antonio López-Vázquez, Carlos López-Larrea

      Pages 27-43

   4. Cellular Immunotolerance in the Transplant

      • Marcos Lóez-Hoyos, David San Segundo, Manuel Arias

      Pages 44-59

   5. Immunosuppression in the ERA of Biological Agents

      • Josep M. Grinyó, Josep M. Cruzado, Oriol Bestard, J. R. Vidal Castiñeira, Joan Torras

      Pages 60-72

   6. Transgenic Organs and Xenotransplants

      • Cristina Costa Vallés, Rafael Máñez Mendiluce

      Pages 73-88

   7. Cell and Tissue Therapy in Regenerative Medicine

      • Ana Sánchez, Thomas Schimmang, Javier García-Sancho

      Pages 89-102

3. Adult Stem Cells

   1. Characteristics of Adult Stem Cells

      • Manuel A. Gonzalez, Antonio Bernad

      Pages 103-120

   2. Bone Marrow Transplantation Extends Its Scope

      • Fermín M. Sánchez-Guijo, Alberto Orfao, María Consuelo del Cañizo

      Pages 121-134

   3. Biology of Stem Cells: The Role of Microenvironments

      • Agustín G. Zapata, David Alfaro, Javier García-Ceca

      Pages 135-151

   4. Mobilization and Homing of Hematopoietic Stem Cells

      • Beatriz Suárez-Álvarez, Antonio López-Vázquez, Carlos López-Larrea

      Pages 152-170

   5. Great Promise of Tissue-Resident Adult Stem/Progenitor Cells in Transplantation and Cancer Therapies

      • Murielle Mimeault, Surinder K. Batra

      Pages 171-186

   6. Multipotent Mesenchymal Stromal Cells: Clinical Applications and Cancer Modeling

      • René Rodríguez, Javier García-Castro, Cesar Trigueros, Mariano García Arranz, Pablo Menéndez

      Pages 187-205

4. Embryonic Stem Cells

   1. Neural Stem Cells and Transplantation Studies in Parkinson’s Disease

      • Ricardo Pardal, José López-Barneo

      Pages 206-216

   2. Biological Impact of Human Embryonic Stem Cells

      • Miguel Martín, Pablo Menéndez

      Pages 217-230

   3. Epigenetics of Embryonic Stem Cells

      • Vincenzo Calvanese, Mario F. Fraga

      Pages 231-253

   4. New Tools in Regenerative Medicine: Gene Therapy

      • Miguel Muñoz Ruiz, José R. Regueiro

      Pages 254-275

   5. Therapeutic Cloning and Cellular Reprogramming

      • Ramon M. Rodriguez, Pablo J. Ross, Jose B. Cibelli

      Pages 276-289

5. Stem Cell Regenerative Medicine

   1. Advances in Stem Cell Therapy

      • Silvia Pérez López, Jesús Otero Hernández

      Pages 290-313

Organ transplantation has been the most important therapeutic advance in the last third of the 20th century. Its development has revolutionized medicine, as demonstrated by the fact that a large number of researchers in this field have been awarded Nobel Prizes. In the beginning of this century, we are witnessing with great expectations the emergence of a new field of medicine related to the arrival of a new player on the scene: “stem cells” and their potential use in regenerative medicine. This volume aims to cover important aspects of the various facets of organ transplantation and regenerative medicine, with leading specialists in these fields setting out their vision. We try to rigorously explain current and novel scientific research in these fields—areas which arouse great interest from society in general, due to their potential use in modern medicine for the treatment of a great number of diseases.

• Cell Therapies
• Embryonic Cell
• López-Larrea
• Stem Cell
• Transplantation

• Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain

  Carlos López-Larrea, Antonio López-Vázquez, Beatriz Suárez-Álvarez

• Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain

  Carlos López-Larrea

Carlos López-Larrea is Professor of Immunology (Oviedo, Spain) and currently Head of the Department of Immunology at the Hospital Universitario Central de Asturias (Oviedo, Spain). He is a world expert on spondyloarthropathies (SpA), in particular MHC and genetic factors that influence the development of the disease. The main research interests of his group also currently include the study of epigenetic mechanisms involved in autoimmune diseases and the role of innate immunity in organ transplantation tolerance. He is a member of several international scientific organizations and board member of several scientific journals. He has published more than 150 international papers and book chapters related to immunology and spondylaorthropathies.

 

Antonio López-Vázquez, MD obtained the degree of Doctor of Medicine in the University of Navarra (Spain) in 1991. Currently, he is an Immunologist in the Department of Immunology of Hospital Universitario Central de Asturias in Oviedo (Spain). He specializes in histocompatibility and autoimmune diseases. Dr. López‑Vázquez’s areas of interest investigation include organ transplantation, celiac disease and HCV infection.

 

Beatriz Suárez‑Álvarez is a research associate in the Histocompatibility Unit of the Immunology Service at the Hospital Universitario Central de Asturias (Oviedo, Spain). She obtained her PhD degree in Biology Sciences (Biochemistry and Molecular Biology) at the University of Oviedo, Spain. Her research project mainly focuses on the regulation of the Major Histocompatibility Complex during the differentiation of human embryonic and induced pluripotent stem cells to different cell types. Her research is based on the study of the epigenetic mechanisms involved in the regulation of genes of the immune system and their role in the development of immune tolerance during transplantation and autoimmune diseases.

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