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Caveolins and Caveolae

Roles in Signaling and Disease Mechanisms

  • Discusses pleiotropic functions of caveolae and caveolin proteins
  • Presents the role and function of caveolae and caveolins in cell signaling and human disease mechanisms
  • Focuses on selected topics

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 729)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xx
  2. Identification and Cellular Functions of Caveolae and Caveolins

    1. Front Matter

      Pages 1-1
    2. Lipid Rafts, Caveolae and GPI-Linked Proteins

      • Valerie L. Reeves, Candice M. Thomas, Eric J. Smart
      Pages 3-13
    3. CAVEOLIN-1: Role in Cell Signaling

      • Cécile Boscher, Ivan Robert Nabi
      Pages 29-50
    4. Regulation of eNOS in Caveolae

      • Chieko Mineo, Philip W. Shaul
      Pages 51-62
  3. Caveolae and Caveolins in Human Diseases

    1. Front Matter

      Pages 63-63
    2. Recent Developments in the Interactions Between Caveolin and Pathogens

      • Fabiana S. Machado, Nilda E. Rodriguez, Daniel Adesse, Luciana R. Garzoni, Lisia Esper, Michael P. Lisanti et al.
      Pages 65-82
    3. Caveolin-1 and Breast Cancer: A New Clinical Perspective

      • Isabelle Mercier, Michael P. Lisanti
      Pages 83-94
    4. Caveolin-1 and Prostate Cancer Progression

      • Michael R. Freeman, Wei Yang, Dolores Di Vizio
      Pages 95-110
    5. Atherosclerosis, Caveolae and Caveolin-1

      • Stephanos Pavlides, Jorge L. Gutierrez-Pajares, Christiane Danilo, Michael P. Lisanti, Philippe G. Frank
      Pages 127-144
    6. Caveolins and Heart Diseases

      • Mathivadhani Panneerselvam, Hemal H. Patel, David M. Roth
      Pages 145-156
    7. Caveolins and Lung Function

      • Nikolaos A. Maniatis, Olga Chernaya, Vasily Shinin, Richard D. Minshall
      Pages 157-179
  4. Back Matter

    Pages 181-184

About this book

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

Editors and Affiliations

  • Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, USA

    Jean-François Jasmin

  • Departments of Cancer Biology, and Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, USA

    Philippe G. Frank, Michael P. Lisanti

About the editors

Jean-François Jasmin, PhD, obtained his degree at the University of Montreal (Montreal, Canada) in 2004. From 2004 to 2007, he was a Post-Doctoral Fellow at both the Albert Einstein College of Medicine (Bronx, NY; Department of Molecular Pharmacology) and the Thomas Jefferson University (Philadelphia, PA; Department of Cancer Biology). Currently, he is an Assistant Professor (Tenure-Track) in the Department of Stem Cell Biology and Regenerative Medicine at the Thomas Jefferson University (Philadelphia, PA). The current focus of his laboratory is on the role of caveolin proteins in the development of cardiovascular and pulmonary diseases.

 

Philippe G. Frank, PhD, obtained his degree in 1998 at the University of Ottawa (Ottawa, Canada), under mentor Professor Yves L. Marcel, a pioneer in lipoprotein studies. Dr. Frank’s doctoral dissertation examined the role and function of apolipoprotein A-I in the reverse cholesterol transport pathway. Also in 1998, he continued his career with a post-doctoral fellowship at the Albert Einstein College of Medicine (Bronx, NY). There, his project focused on the role of caveolin proteins in cancer and atherosclerosis, in addition to lipoprotein and cholesterol metabolism. In 2006, he joined the Kimmel Cancer Center as an Assistant Professor at Thomas Jefferson University in Philadelphia, Pennsylvania, where he focuses on the role of lipoproteins in cancer and vascular diseases.

 

Michael P. Lisanti, MD, PhD, obtained his degrees at Cornell University Medical College (New York, NY) in 1992. From 1992-97, he was a Fellow at the Whitehead Institute at MIT (Cambridge, MA), affiliated with Dr. Harvey Lodish’s laboratory. Currently, he is Chairman of the Stem Cell Biology and Regenerative Medicine Department, Leader/ Director of the Program in Molecular Biology and Genetics of Cancer, and Director of the Stem Cell Biology and Regenerative Medicine Center at the Thomas Jefferson University(Philadelphia, PA) as well as Editor-in-Chief of the American Journal of Pathology. The current focus of his laboratory is on the role of caveolin-1 in cancer pathogenesis.

Bibliographic Information

  • Book Title: Caveolins and Caveolae

  • Book Subtitle: Roles in Signaling and Disease Mechanisms

  • Editors: Jean-François Jasmin, Philippe G. Frank, Michael P. Lisanti

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-1222-9

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-1221-2Published: 30 January 2012

  • eBook ISBN: 978-1-4614-1222-9Published: 12 March 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XX, 184

  • Number of Illustrations: 26 b/w illustrations, 1 illustrations in colour

  • Topics: Biomedicine general

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access