Endocrine FGFs and Klothos

1. Front Matter

   Pages i-xix

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2. The Structural Biology of the FGF19 Subfamily

   • Andrew Beenken, Moosa Mohammadi

   Pages 1-24

3. Klotho and βKlotho

   • Makoto Kuro-o

   Pages 25-40

4. FGF23 and Syndromes of Abnormal Renal Phosphate Handling

   • Clemens Bergwitz, Harald Jüppner

   Pages 41-64

5. Evidence for FGF23 Involvement in a Bone-Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis

   • Aline Martin, L. Darryl Quarles

   Pages 65-83

6. FGF23, Klotho and Vitamin D Interactions:

   • M. Shawkat Razzaque

   Pages 84-91

7. FGF23 and the Parathyroid

   • Justin Silver, Tally Naveh-Many

   Pages 92-99

8. Regulation of Ion Channels by Secreted Klotho

   • Chou-Long Huang

   Pages 100-106

9. FGF23 in Chronic Kidney Disease

   • Patricia Wahl, Myles Wolf

   Pages 107-125

10. Secreted Klotho and Chronic Kidney Disease

    • Ming Chang Hu, Makoto Kuro-o, Orson W. Moe

    Pages 126-157

11. FGF23 as a Novel Therapeutic Target

    • Takashi Shimada, Seiji Fukumoto

    Pages 158-170

12. Physiology of FGF15/19

    • Stacey A. Jones

    Pages 171-182

13. FGF19 and Cancer

    • Benjamin C. Lin, Luc R. Desnoyers

    Pages 183-194

14. Understanding the Structure-Function Relationship between FGF19 and Its Mitogenic and Metabolic Activities

    • Xinle Wu, Yang Li

    Pages 195-213

15. FGF21 as a Therapeutic Reagent

    • Yang Zhao, James D. Dunbar, Alexei Kharitonenkov

    Pages 214-228

16. Back Matter

    Pages 229-233

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Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

• Endocrine
• FGF
• Fibroblast growth factor
• Klotho
• Kuro-o
• gene expression

• Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, USA

  Makoto Kuro-o

MAKOTO KURO-O is an Associate Professor in the Pathology Department at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern). He also has an appointment to the Pak Center for Mineral Metabolism and the Simmons Comprehensive Cancer Center in UT Southwestern. He received his MD and PhD from the University of Tokyo, Japan. His major research interests include molecular mechanisms of aging and age-related diseases with special reference to chronic kidney disease. He is a member of the American Society of Nephrology (ASN).

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