Overview
Identifies a molecular phenotype for modified stem cells
Looks into the first challenge of molecular oncology
Gives insight into pathogenetic mechanisms at the basis of cancer stem cells
Includes supplementary material: sn.pub/extras
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Table of contents(18 chapters)
About this book
In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.
Editors and Affiliations
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, Department of Laboratory Medicine, Catholic University, Rome, Italy
Roberto Scatena, Bruno Giardina
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School of Medicine, Institute of Biochemistry, Catholic University, Rome, Italy
Alvaro Mordente
Bibliographic Information
Book Title: Advances in Cancer Stem Cell Biology
Editors: Roberto Scatena, Alvaro Mordente, Bruno Giardina
DOI: https://doi.org/10.1007/978-1-4614-0809-3
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2012
Hardcover ISBN: 978-1-4614-0808-6Published: 05 October 2011
Softcover ISBN: 978-1-4939-0059-6Published: 08 December 2014
eBook ISBN: 978-1-4614-0809-3Published: 06 October 2011
Edition Number: 1
Number of Pages: XII, 343
Topics: Cancer Research, Pharmacology/Toxicology