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  • © 2012

Bioinformatics for High Throughput Sequencing

  • This book looks at all aspects of next generation sequencing data analysis, and focuses on the practical issues

  • Guidelines are given for the analysis of the data obtained from each experiment

  • A close look at a rapidly expanding type of facility that will soon be available in almost every laboratory worldwide

  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
  2. Introduction

    • Naiara Rodríguez-Ezpeleta, Ana M. Aransay
    Pages 1-9
  3. Overview of Sequencing Technology Platforms

    • Samuel Myllykangas, Jason Buenrostro, Hanlee P. Ji
    Pages 11-25
  4. Applications of High-Throughput Sequencing

    • Rodrigo Goya, Irmtraud M. Meyer, Marco A. Marra
    Pages 27-53
  5. Base-Calling for Bioinformaticians

    • Mona A. Sheikh, Yaniv Erlich
    Pages 67-83
  6. De Novo Short-Read Assembly

    • Douglas W. Bryant Jr., Todd C. Mockler
    Pages 85-105
  7. Short-Read Mapping

    • Paolo Ribeca
    Pages 107-125
  8. Generation and Analysis of Genome-Wide DNA Methylation Maps

    • Martin Kerick, Axel Fischer, Michal-Ruth Schweiger
    Pages 151-167
  9. Differential Expression for RNA Sequencing (RNA-Seq) Data: Mapping, Summarization, Statistical Analysis, and Experimental Design

    • Matthew D. Young, Davis J. McCarthy, Matthew J. Wakefield, Gordon K. Smyth, Alicia Oshlack, Mark D. Robinson
    Pages 169-190
  10. MicroRNA Expression Profiling and Discovery

    • Michael Hackenberg
    Pages 191-208
  11. Analysis of Metagenomics Data

    • Elizabeth M. Glass, Folker Meyer
    Pages 219-229
  12. Back Matter

    Pages 249-255

About this book

Next generation sequencing is revolutionizing molecular biology. Owing to this new technology it is now possible to carry out a panoply of experiments at an unprecedented low cost and high speed. These go from sequencing whole genomes, transcriptomes and small non-coding RNAs to description of methylated regions, identification protein – DNA interaction sites and detection of structural variation. The generation of gigabases of sequence information for each of this huge bandwidth of applications in just a few days makes the development of bioinformatics applications for next generation sequencing data analysis as urgent as challenging.

Editors and Affiliations

  • CIC bioGUNE, Genome Analysis Platform, Derio, Spain

    Naiara Rodríguez-Ezpeleta, Ana M. Aransay

  • Computational Genomics and Bioinformatic, University of Granada, Granada, Spain

    Michael Hackenberg

Bibliographic Information

  • Book Title: Bioinformatics for High Throughput Sequencing

  • Editors: Naiara Rodríguez-Ezpeleta, Michael Hackenberg, Ana M. Aransay

  • DOI: https://doi.org/10.1007/978-1-4614-0782-9

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4614-0781-2Published: 25 October 2011

  • Softcover ISBN: 978-1-4899-9876-7Published: 25 October 2014

  • eBook ISBN: 978-1-4614-0782-9Published: 26 October 2011

  • Edition Number: 1

  • Number of Pages: XI, 255

  • Number of Illustrations: 4 b/w illustrations, 25 illustrations in colour

  • Topics: Bioinformatics, Human Genetics, Biomedicine general

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access