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Tumour-Associated Macrophages

  • Book
  • © 2012

Overview

Editors:
  1. Toby Lawrence

    1. Inserm-CNRS-Universitie de Mediteranee, Inflammation Biology Group, Centre d'Immunologie Marseille Luminy, Marseille, France

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  2. Thorsten Hagemann

    1. Barts & The London Queen Mary's, School of Medicine & Dentistry, Queen Mary, University of London, London, United Kingdom

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  • Among the first books to collectively discuss a definitive theory on the role of macrophage in tumor development

  • The book appeals to basic scientist working in immunology tumor biology and to some extent pharmacology and biochemistry, clinicians involved in preclinical tumor biology research

  • Research and intensive discussion of Ik-B and NF-kB

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xi
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  2. Form and Function

    1. Front Matter

      Pages 1-1
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  3. Form and function

    1. Macrophage Phenotype in Tumours

      • Hsi-Hsien Lin, Siamon Gordon
      Pages 3-16

    2. Role of Tumour-Associated Macrophages in the Regulation of Angiogenesis

      • Russell Hughes, Hsin-Yu Fang, Munitta Muthana, Claire E. Lewis
      Pages 17-29

    3. The Role of Tumour-Associated Macrophages in Malignant Invasion

      • Claudia Binder
      Pages 31-47

    4. Tumour-Induced Immune Suppression by Myeloid Cells

      • Serena Zilio, Giacomo Desantis, Mariacristina Chioda, Vincenzo Bronte
      Pages 49-62

    5. TAM: A Moving Clinical Target

      • Simon Hallam, Thorsten Hagemann
      Pages 63-73

  4. Mechanisms of Action

    1. Front Matter

      Pages 75-75
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  5. Mechanisms of action

    1. Arginine Metabolism and Tumour-Associated Macrophages

      • Melissa Phillips, Peter W. Szlosarek
      Pages 77-90

    2. Indoleamine 2,3-Dioxygenase Amino Acid Metabolism and Tumour-Associated Macrophages: Regulation in Cancer-Associated Inflammation and Immune Escape

      • George C. Prendergast, Richard Metz, Mee Young Chang, Courtney Smith, Alexander J. Muller, Suzanne Ostrand-Rosenberg
      Pages 91-104

    3. Vascular Endothelial Growth Factor and Tumour-Associated Macrophages

      • Christian Stockmann, Randall S. Johnson
      Pages 105-115

  6. Molecular Regulation

    1. Front Matter

      Pages 117-117
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  7. Molecular regulation

    1. TLR Signaling and Tumour-Associated Macrophages

      • Oscar R. Colegio, Ruslan Medzhitov
      Pages 119-133

    2. SHIP and Tumour-Associated Macrophages

      • Victor W. Ho, Melisa J. Hamilton, Etsushi Kuroda, Jens Ruschmann, Frann Antignano, Vivian Lam et al.
      Pages 135-151

    3. NF-KappaB-Mediated Regulation of Tumour-Associated Macrophages: Mechanisms and Significance

      • Antonio Sica, Alberto Mantovani
      Pages 153-165

    4. Role of Hypoxia-Inducible Transcription Factors in TAM Function

      • Nadine Rohwer, Thorsten Cramer
      Pages 167-181

  8. Back Matter

    Pages 183-187
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Keywords

About this book

The subject of Tumour-Associated Macrophages is of interest in the cancer research community, and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development.

Editors and Affiliations

  • Inserm-CNRS-Universitie de Mediteranee, Inflammation Biology Group, Centre d'Immunologie Marseille Luminy, Marseille, France

    Toby Lawrence

  • Barts & The London Queen Mary's, School of Medicine & Dentistry, Queen Mary, University of London, London, United Kingdom

    Thorsten Hagemann

Bibliographic Information

  • Book Title: Tumour-Associated Macrophages

  • Editors: Toby Lawrence, Thorsten Hagemann

  • DOI: https://doi.org/10.1007/978-1-4614-0662-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4614-0661-7Published: 05 October 2011

  • Softcover ISBN: 978-1-4899-9925-2Published: 28 November 2014

  • eBook ISBN: 978-1-4614-0662-4Published: 06 October 2011

  • Edition Number: 1

  • Number of Pages: XI, 187

  • Topics: Cancer Research, Pharmacology/Toxicology

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