Editors:
- Highlights the latest findings on the current state of human cell transformation model systems
- Provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells
- Covers all recently developed novel human cell models
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 720)
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Table of contents (18 chapters)
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Front Matter
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Multistep Models
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Front Matter
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Prostate Cancer/Stem Cells
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Front Matter
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About this book
Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells.
Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including:
· Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems
· Oncogenes
· Tumor suppressor genes
· Viral transformation
· In vitro model systems for viral, chemical and radiation carcinogenesis
· Cell aging
· The multistep nature of human carcinogenesis
· The role of stem cells and the microenvironment in tumorigenesis· The genes involved in multistep carcinogenesis
Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields.
Essential reading for everyone who needs to be kept up-to-date in this fast-paced area!
Features
Ø Multistep models
Ø Breast cancer/Stem cells
Ø Prostate cancer/Stem cells
Ø Multistep / Genes
Editors and Affiliations
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Uniformed Services, Department of Surgery, University of the Health Sciences, Bethesda, USA
Johng S. Rhim
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, Department of Medicine, McGill University Health Centre, Montreal, Canada
Richard Kremer
Bibliographic Information
Book Title: Human Cell Transformation
Book Subtitle: Role of Stem Cells and the Microenvironment
Editors: Johng S. Rhim, Richard Kremer
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4614-0254-1
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012
Hardcover ISBN: 978-1-4614-0253-4Published: 08 September 2011
Softcover ISBN: 978-1-4939-4164-3Published: 23 August 2016
eBook ISBN: 978-1-4614-0254-1Published: 15 September 2011
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XXII, 224
Topics: Cell Biology, Stem Cells