Active Oxygen in Biochemistry

1. Front Matter

   Pages i-xvii

   PDF

2. Biological Reactions of Dioxygen: An Introduction

   • Raymond Y. N. Ho, Joel F. Liebman, Joan Selverstone Valentine

   Pages 1-36

3. Oxygen Activation by Flavins and Pterins

   • Bruce A. Palfey, David P. Ballou, Vincent Massey

   Pages 37-83

4. Reactions of Dioxygen and Its Reduced Forms with Heme Proteins and Model Porphyrin Complexes

   • Teddy G. Traylor, Patricia S. Traylor

   Pages 84-187

5. Dioxygen Reactivity in Copper Proteins and Complexes

   • Stephen Fox, Kenneth D. Karlin

   Pages 188-231

6. Oxygen Activation at Nonheme Iron Centers

   • Lawrence Que Jr.

   Pages 232-275

7. The Mechanism of Lipoxygenases

   • Mark J. Nelson, Steven P. Seitz

   Pages 276-312

8. The Biological Significance of Oxygen-Derived Species

   • Barry Halliwell

   Pages 313-335

9. Metal-Complex-Catalyzed Cleavage of Biopolymers

   • Rosemary A. Marusak, Claude F. Meares

   Pages 336-400

10. Exploration of Selected Pathways for Metabolic Oxidative Ring Opening of Benzene Based on Estimates of Molecular Energetics

    • Arthur Greenberg

    Pages 401-432

11. The Role of Oxidized Lipids in Cardiovascular Disease

    • Judith A. Berliner, Andrew D. Watson

    Pages 433-449

12. Back Matter

    Pages 451-463

    PDF

The field of "Oxygen Activation" has attracted considerable interest recently, not only because it presents challenges in those fields of basic research that aim to understand the fundamental aspects of chemical and biological reactions that involve dioxygen, but also because of its wide range of practical implications in such diverse fields as medicine, synthesis of pharmaceuticals and other organic compounds, materials science, and atmospheric science. This is the second of two volumes that focus on the subject of oxygen activation, the first slanted toward chemistry and the second toward biological chemistry. We planned these volumes to be more general than many monographs of this sort, not as detailed summaries of the authors' own research but rather as general overviews of the field. Our choice of topics was strongly influenced by our syllabus for a course entitled "Oxygen Chemistry," which two of us have twice taught jointly at UCLA. Definition of important issues, horizons, and future prospects was an important goal, and, although totally comprehensive coverage was not possible, we believe that we have chosen a representative selection of research topics current to the field. We have targeted this work to a diverse audience ranging from professionals in fields from physics to medicine to beginning graduate students who are interested in rapidly acquiring the basics of this field.

• biochemistry
• chemistry
• protein
• science
• synthesis

• University of California, Los Angeles, USA

  Joan Selverstone Valentine, Christopher S. Foote

• University of North Carolina at Charlotte, USA

  Arthur Greenberg

• University of Maryland Baltimore County, USA

  Joel F. Liebman

Policies and ethics