Preimplantation Embryo Development

1. Front Matter

   Pages i-xvi

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2. Development of the Oocyte

   1. Front Matter

      Pages 1-1

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   2. Nuclear and Cytoplasmic Changes During Oocyte Maturation

      • David F. Albertini, Dineli Wickramasinghe, Susan Messinger, Britta A. Mattson, Carlos E. Plancha

      Pages 3-21

   3. Follicular Control of Meiotic Maturation in Mammalian Oocytes

      • Catherine Racowsky

      Pages 22-37

   4. Translation Control in Oocytes: A Critical Role for the Poly(A) Tail of Maternal mRNAs

      • Marcia L. O’Connell, Joaquin Huarte, Dominique Belin, Jean-Dominique Vassalli, Sidney Strickland

      Pages 38-42

   5. Establishment of Competence for Preimplantation Embryogenesis during Oogenesis in Mice

      • John J. Eppig

      Pages 43-53

3. Epigenetic Control of Embryo Development

   1. Front Matter

      Pages 55-55

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   2. Regulation of Hamster Embryo Development In Vitro by Amino Acids

      • Barry D. Bavister, Susan H. McKiernan

      Pages 57-72

   3. Energy Metabolism in Preimplantation Development

      • Henry J. Leese

      Pages 73-82

   4. Growth Factors as Regulators of Mammalian Preimplantation Embryo Development

      • Bernd Fischer

      Pages 83-96

   5. Intracellular pH Regulation by the Preimplantation Embryo

      • Jay M. Baltz, John D. Biggers, Claude Lechene

      Pages 97-111

4. Genetics of Embryo Development

   1. Front Matter

      Pages 113-113

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   2. Activation of the Embryonic Genome: Comparisons Between Mouse and Bovine Development

      • Andrew J. Watson, Aileen Hogan, Ann Hahnel, Gilbert A. Schultz

      Pages 115-130

   3. Mutations Affecting Early Development in the Mouse

      • Terry Magnuson, Shyam K. Sharan, Bernadette Holdener-Kenny

      Pages 131-143

   4. Parental Imprinting in Mammalian Development

      • Anne C. Ferguson-Smith, M. Azim Surani

      Pages 144-156

   5. Developmental Potential of Mouse Embryonic Stem Cells

      • Janet Rossant, Elizabeth Merentes-Diaz, Elen Gocza, Eszter Ivanyi, Andras Nagy

      Pages 157-165

5. Differentiation of the Embryo

   1. Front Matter

      Pages 167-167

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   2. Blastocyst Development and Growth: Role of Inositol and Citrate

      • M. T. Kane, M. M. Fahy

      Pages 169-183

   3. Development of Human Blastocysts In Vitro

      • Kate Hardy

      Pages 184-199

   4. Development of Na/K ATPase Activity and Blastocoel Formation

      • Catherine S. Gardiner, Alfred R. Menino Jr.

      Pages 200-210

This volume contains the Proceedings of the Serono Symposium on Pre­ implantation Embryo Development, held in Newton, Massachusetts, in 1991. The idea for the symposium grew out of the 1989 Serono Symposium on Fertilization in Mammals* at which preimplantation development was the predominant suggestion for a follow-up topic. This was indeed a timely subject in view of the recent resurgence of interest in this funda­ mental phase of embryogenesis and its relevance to basic research and applied fertility studies in humans, food-producing animals, and endangered species. The symposium brought together speakers from a broad range of disciplines in order to focus on key regulatory mechanisms in embryo development, using a wide variety of animal models, and on representative topics in human preimplantation embryogenesis. The culmination of preimplantation development is a blastocyst con­ taining the first differentiated embryonic tissues and capable of initiating and sustaining pregnancy. The central objective of the symposium was to throw light on the regulation of cellular and molecular events underlying blastocyst formation. It was particularly appropriate that the date of the symposium marked the 20th anniversary of the publication of the classic volume Biology of the Blastocyst, the proceedings of an international workshop held in 1970. This book, which summarized most of the information then available on this topic in mammals, was edited by the pioneer in blastocyst research, Dr. Richard B1andau, who was the guest speaker at the symposium.

• ATP
• Activation
• Amino acid
• Embryologie
• Fruchtbarkeit
• metabolism
• regulation
• tissue
• translation

• Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, Madison, USA

  Barry D. Bavister

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