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Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Peter E. Lipsky

    1. Internal Medicine and Microbiology, University of Texas Southwestern Medical Center at Dallas, Dallas, USA

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  2. Robert Rothlein

    1. Cellular Adhesion/Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

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  3. Takashi Kei Kishimoto

    1. Cellular Adhesion/Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

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  4. Ronald B. Faanes

    1. R&D Scientific and Technical Operations, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

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  5. C. Wayne Smith

    1. Department of Pediatrics Leukocyte Biology Section, Texas Children’s Hospital Clinical Care Center, Houston, USA

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Table of contents (33 papers)

  1. Front Matter

    Pages i-xxiv
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  2. Structure and Function of the Integrins

    1. Front Matter

      Pages 1-1
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    2. Leukocyte Integrin Activation

      • Nancy Hogg, Carlos Cabañas, Ian Dransfield
      Pages 3-13

    3. Activation of LFA-1: Role of Cations

      • Carl G. Figdor, Yvette van Kooyk
      Pages 14-24

    4. An Antibody That Promotes Adhesion Events Mediated by Both LFA-1 and CR3

      • Martyn K. Robinson, David Andrew, Hugh Rosen, Derek Brown, Susan Ortlepp, P. Stephens et al.
      Pages 25-33

    5. Function of a Soluble Human β2 Integrin CD11b/CD18

      • Nava Dana, Dehmani M. Fathallah, M. Amin Arnaout
      Pages 34-44

    6. Mac-1 (CD11b/CD18) and Adherence-Dependent Neutrophil Locomotion

      • B. J. Hughes, J. C. Hollers, C. Wayne Smith
      Pages 45-57

    7. Functional Comparison of the Integrins α 4 β 1 (VLA-4) and α 4 β 7

      • Bosco M. C. Chan, Mariano J. Elices, Martin E. Hemler
      Pages 58-66

    8. Functional Mapping and Regulation of VLA-4 Adhesion Activities

      • Francisco Sánchez-Madrid, Rafael Pulido, Antonio A. Postigo, Miguel R. Campanero, Alicia G. Arroyo, Rosario GarcĂ­a-Vicuña et al.
      Pages 67-77

    9. Signal Transduction Through a Novel Phagocyte Integrin

      • Eric J. Brown, Hattie D. Gresham
      Pages 78-91

    10. Interations of the Plasmodium falciparum—Infected Erythrocyte with ICAM-1

      • Anthony R. Berendt, Alison McDowall, Alister G. Craig, Paul A. Bates, Christopher I. Newbold, Nancy Hogg
      Pages 92-103

  3. Structure and Function of the Selectins

    1. Front Matter

      Pages 105-105
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    2. The Selectins

      • Takashi Kei Kishimoto
      Pages 107-134

    3. Leukocyte Interactions Mediated by P-Selection

      • Rodger P. McEver
      Pages 135-150

    4. PMN Extravasation in Acute Inflammation: A Role for Selectin Interaction in Initial PMN-Endothelial Cell Recognition

      • Louis J. Picker, Ulrich H. von Andrian, Alan R. Burns, Claire M. Doerschuk, Karl-E. Arfors, Eugene C. Butcher
      Pages 151-167

    5. Interaction of LAM-1 with an Inducible Ligand Supports Leukocyte Adhesion to Endothelium

      • Geoffrey S. Kansas, Olivier Spertini, Francis W. Luscinskas, Michael Gimbrone, Thomas F. Tedder
      Pages 168-181

    6. The Contribution of L-Selectin to Leukocyte Trafficking In Vivo

      • Bruce Walcheck, Mark A. Jutila
      Pages 182-190

    7. L-Selectin as a Mediator of Leukocyte Binding to Myelinated Tracts of the Central Nervous System: Possible Pathophysiologic Significance

      • Steven D. Rosen, Kun Huang
      Pages 191-199

    8. Selectin-Dependent Monocyte Adhesion in Frozen Sections of Rheumatoid Synovitis

      • L. M. Stoolman, J. Grober, B. Bowen, P. Reddy, J. Shih, C. Thompson et al.
      Pages 200-213

  4. Cell Biology of Adhesion Molecules

    1. Front Matter

      Pages 215-215
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Keywords

About this book

Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. The blend of basic science and clinical applications presented in Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion provides clear evidence of the biological importance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion. It will appeal to a broad range of readers in immunology and cell biology.

Editors and Affiliations

  • Internal Medicine and Microbiology, University of Texas Southwestern Medical Center at Dallas, Dallas, USA

    Peter E. Lipsky

  • Cellular Adhesion/Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

    Robert Rothlein, Takashi Kei Kishimoto

  • R&D Scientific and Technical Operations, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

    Ronald B. Faanes

  • Department of Pediatrics Leukocyte Biology Section, Texas Children’s Hospital Clinical Care Center, Houston, USA

    C. Wayne Smith

Bibliographic Information

  • Book Title: Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

  • Editors: Peter E. Lipsky, Robert Rothlein, Takashi Kei Kishimoto, Ronald B. Faanes, C. Wayne Smith

  • DOI: https://doi.org/10.1007/978-1-4613-9266-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1993

  • Softcover ISBN: 978-1-4613-9268-2Published: 09 November 2011

  • eBook ISBN: 978-1-4613-9266-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIV, 396

  • Topics: Infectious Diseases, Cell Biology, Biochemistry, general, Immunology

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