Overview
- Editors:
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Jonathan J. Li
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Hormonal Carcinogenesis Laboratory and Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, USA
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Satyabrata Nandi
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Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, USA
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Sara Antonia Li
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Hormonal Carcinogenesis Laboratory and Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, USA
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Table of contents (51 papers)
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Front Matter
Pages i-xxxiv
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Sex Hormones and Carcinogenesis
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- Shuk-Mei Ho, Margaret Yu, Irwin Leav, Todd Viccione
Pages 18-26
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- Tomoyuki Shirai, Seiko Tamano, Shogo Iwasaki, Nobuyuki Ito
Pages 27-32
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- James S. Norris, David A. Schwartz, Tina Cooper, Weimin Fan
Pages 33-40
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Hormones, Cell Proliferation, and Carcinogenesis
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- John A. McLachlan, Retha R. Newbold, Karen G. Nelson, Kenneth S. Korach
Pages 51-57
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- Alberto Baldi, Denis M. Boyle, Nestor V. Annibali, James L. Wittliff
Pages 58-64
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- Craig W. Beattie, Conwell H. Anderson
Pages 65-72
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- Satyabrata Nandi, Raphael C. Guzman, Shigeki Miyamoto
Pages 73-77
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Estrogen Metabolism and Carcinogenicity
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- Allan H. Conney, Lisa A. Suchar, Shuzo Okumura, Richard L. Chang
Pages 81-85
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- Manfred Metzler, Erika Pfeiffer, Werner Köhl, Robert Schnitzler
Pages 86-94
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- Jack Fishman, George Swaneck
Pages 95-103
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- Sara Antonia Li, Jonathan J. Li
Pages 110-117
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Hormones and Tumor Promotion
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Front Matter
Pages 119-119
About this book
In the past decade there has been a growing public interest and resurgence in research in the field of hormonal carcinogenesis. This is due to the widespread use of therapeutic hormonal agents worldwide and to the increasing awareness of the causal association of hormones, both endogenous and exogenously administered, and a variety of human cancers. These associations include estrogens in uterine, cervical, vaginal, liver, testicular, prostatic, and possible breast cancers; progesterone and progestational hormones in breast cancer; androgens and anabolic steroids in hepatic and prostatic cancers. Additionally, gonadotrophins playa role in the etiology of ovarian and testicular cancers and thyroid-stimulating hormones in thyroid cancers. Therefore, hormonal carcinogenesis encompasses the study of both natural and synthetic hormonal agents, including growth factors and other peptide and protein factors, which contribute substantially to the etiology of both human and animal neoplasms, benign or malignant. Hormones may be involved in all aspects of neoplastic transformation, including initiation, promotion, and progression, and the inhibition of these processes. There are a number of important issues in women's health that need to be addressed. More than 40 million U. S. women are menopausal, and these women have a life expectancy of over 30 years after the menopause. When these figures are multiplied worldwide, the numbers become staggering. After the menopause, estrogen replacement therapy (ERT) is the choice of most women in industrialized countries.
