DNA Methylation

1. Front Matter

   Pages i-xiii

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2. Introduction and General Overview

   • Aharon Razin, Howard Cedar, Arthur D. Riggs

   Pages 1-10

3. Type I and Type III Restriction-Modification Enzymes

   • Robert Yuan, Daniel L. Hamilton

   Pages 11-37

4. Methylases of the Type II Restriction-Modification Systems

   • Hamilton O. Smith, Samuel V. Kelly

   Pages 39-71

5. The Restriction and Modification DNA Methylases: An Overview

   • Robert Yuan, Hamilton O. Smith

   Pages 73-80

6. Methylation of Prokaryotic DNA

   • M. G. Marinus

   Pages 81-109

7. DNA Methylation: DNA Replication and Repair

   • Robert H. Grafstrom, Daniel L. Hamilton, Robert Yuan

   Pages 111-126

8. DNA Methylation Patterns: Formation and Biological Functions

   • Aharon Razin

   Pages 127-146

9. DNA Methylation and Gene Expression

   • Howard Cedar

   Pages 147-164

10. Gene Activation by 5-Azacytidine

    • Peter A. Jones

    Pages 165-187

11. DNA Methylation in Early Mammalian Development

    • Detlev Jähner, Rudolf Jaenisch

    Pages 189-219

12. Specific Promoter Methylations Cause Gene Inactivation

    • Walter Doerfler, Klaus-Dieter Langner, Inge Kruczek, Lily Vardimon, Doris Renz

    Pages 221-247

13. DNA Methylation and Developmental Regulation of Eukaryotic Globin Gene Transcription

    • Che-Kun James Shen

    Pages 249-268

14. X Inactivation, DNA Methylation, and Differentiation Revisited

    • Arthur D. Riggs

    Pages 269-278

15. Left-handed Z-DNA and Methylation of d(CpG) Sequences

    • Alexander Rich

    Pages 279-292

16. Chromatin Structure and Gene Expression

    • Kathleen F. Conklin, Mark Groudine

    Pages 293-351

17. Gene Methylation Patterns and Expression

    • Joel Yisraeli, Moshe Szyf

    Pages 353-378

18. Back Matter

    Pages 379-392

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During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was trans­ mitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for rep­ licating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living sys­ tems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a description of the frontiers of research where our knowledge is increasing steadily.

• Activation
• DNA
• biochemistry
• biology
• enzymes
• gene expression
• methylation
• molecular biology
• molecular mechanisms
• nucleic acid
• protein
• proteins
• regulation
• replication
• transcription

• Department of Cellular Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel

  Aharon Razin

• Department of Cellular Biochemistry, The Hebrew University Hadassah Medical School, Jerusalem, Israel

  Howard Cedar

• Beckman Research Institute of the City of Hope, Duarte, USA

  Arthur D. Riggs

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