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Cell Mechanics and Cellular Engineering

  • Book
  • © 1994

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Editors:
  1. Van C. Mow

    1. Orthopaedic Research Laboratory, Columbia University, New York, USA

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  2. Roger Tran-Son-Tay

    1. Department of Aerospace Engineering, Mechanics and Engineering Science, University of Florida, Gainesville, USA

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  3. Farshid Guilak

    1. Musculo-Skeletal Research Laboratory, Department of Orthopaedics, Health Science Center, State University of New York, Stony Brook, USA

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  4. Robert M. Hochmuth

    1. Department of Mechanical Engineering and Material Sciences, Duke University, Durham, USA

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Constitutive Modeling and Mechanical Properties of Circulating Cells

    1. Front Matter

      Pages 1-1
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    2. Human Neutrophils Under Mechanical Stress

      • D. V. Zhelev, R. M. Hochmuth
      Pages 3-21

    3. Viscous Behavior of Leukocytes

      • R. Tran-Son-Tay, H. P. Ting-Beall, D. V. Zhelev, R. M. Hochmuth
      Pages 22-32

    4. Shear Rate-Dependence of Leukocyte Cytoplasmic Viscosity

      • R. E. Waugh, M. A. Tsai
      Pages 33-44

    5. Cell Tumbling in Laminar Flow: Cell Velocity is a Unique Function of the Shear Rate

      • A. Tözeren
      Pages 45-52

  3. Flow-Induced Effects on Cell Morphology and Function

    1. Front Matter

      Pages 53-53
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    2. The Regulation of Vascular Endothelial Biology by Frow

      • R. M. Nerem, P. R. Girard, G. Helmlinger, O. Thoumine, T. F. Wiesner, T. Ziegler
      Pages 55-69

    3. Flow Modulation of Receptor Function in Leukocyte Adhesion to Endothelial Cells

      • D. A. Jones, C. W. Smith, L. V. McIntire
      Pages 70-94

    4. Osteoblast Responses to Steady Shear Stress

      • H. Y. Shin, R. D. Iveson, F. A. Blumenstock, R. Bizios
      Pages 95-106

    5. Effects of Shear Stress on Cytoskeletal Structure and Physiological Functions of Cultured Endothelial Cells

      • N. Ohshima, K. Ookawa
      Pages 107-117

  4. Mechanics and Biology of Cell-Substrate Interactions

    1. Front Matter

      Pages 119-119
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    2. Kinetics and Mechanics of Cell Adhesion under Hydrodynamic Flow: Two Cell Systems

      • D. A. Hammer, L. A. Tempelman, D. J. Goetz
      Pages 121-144

    3. Initial Steps of Cell-Substrate Adhesion

      • A. Pierres, A. M. Benoliel, P. Bongrand
      Pages 145-159

    4. A Cell-Cell Adhesion Model for the Analysis of Micropipette Experiments

      • C. Zhu, T. E. Williams, J. Delobel, D. Xia, M. K. Offermann
      Pages 160-181

  5. Cell-Matrix Interactions and Adhesion Molecules

    1. Front Matter

      Pages 183-183
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    2. Biphasic Theory and In Vitro Assays of Cell-Fibril Mechanical Interactions in Tissue-Equivalent Gels

      • V. H. Barocas, R. T. Tranquillo
      Pages 185-209

    3. Mechanical Load ± Growth Factors Induce [Ca2+]i Release, Cyclin D1 Expression and DNA Synthesis in Avian Tendon Cells

      • A. J. Banes, M. Sanderson, S. Boitano, P. Hu, B. Brigman, M. Tsuzaki et al.
      Pages 210-232

    4. Cytomechanics of Transdifferentiation

      • M. Opas
      Pages 233-252

  6. Molecular and Biophysical Mechanisms of Mechanical Signal Transduction

    1. Front Matter

      Pages 253-253
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Keywords

About this book

Cell mechanics and cellular engineering may be defined as the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological cells and the development of biological substitutes to restore cellular functions. This definition is derived from one developed for tissue engineering at a 1988 NSF workshop. The reader of this volume will see the definition being applied and stretched to study cell and tissue structure-function relationships. The best way to define a field is really to let the investigators describe their areas of study. Perhaps cell mechanics could be compartmentalized by remembering how some of the earliest thinkers wrote about the effects of mechanics on growth. As early as 1638, Galileo hypothesized that gravity and of living mechanical forces place limits on the growth and architecture organisms. It seems only fitting that Robert Hooke, who gave us Hooke's law of elasticity, also gave us the word "cell" in his 1665 text, Micrographid, to designate these elementary entities of life. Julius Wolffs 1899 treatise on the function and form of the trabecular architecture provided an incisive example of the relationship between the structure of the body and the mechanical load it bears. In 1917, D' Arcy Thompson's On Growth and Form revolutionized the analysis of biological processes by introducing cogent physical explanations of the relationships between the structure and function of cells and organisms.

Editors and Affiliations

  • Orthopaedic Research Laboratory, Columbia University, New York, USA

    Van C. Mow

  • Department of Aerospace Engineering, Mechanics and Engineering Science, University of Florida, Gainesville, USA

    Roger Tran-Son-Tay

  • Musculo-Skeletal Research Laboratory, Department of Orthopaedics, Health Science Center, State University of New York, Stony Brook, USA

    Farshid Guilak

  • Department of Mechanical Engineering and Material Sciences, Duke University, Durham, USA

    Robert M. Hochmuth

Bibliographic Information

  • Book Title: Cell Mechanics and Cellular Engineering

  • Editors: Van C. Mow, Roger Tran-Son-Tay, Farshid Guilak, Robert M. Hochmuth

  • DOI: https://doi.org/10.1007/978-1-4613-8425-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York, Inc. 1994

  • Softcover ISBN: 978-1-4613-8427-4Published: 08 November 2011

  • eBook ISBN: 978-1-4613-8425-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVII, 564

  • Topics: Cell Biology

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