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Ticlopidine, Platelets and Vascular Disease

  • Book
  • © 1993

Overview

Editors:
  1. William K. Hass

    1. Department of Neurology, New York University School of Medicine, New York, USA

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  2. J. Donald Easton

    1. Department of Neurology, Brown University Medical Center, Providence, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (10 chapters)

  1. Front Matter

    Pages iii-xi
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  2. Changing Concepts of the Pathophysiology of Cerebral and Myocardial Infarction

    • William K. Hass, J. Donald Easton
    Pages 1-12

  3. Overview of Ticlopidine’s Development

    • Edouard Panak, Monique Verry
    Pages 13-25

  4. Pharmacodynamics and Pharmacokinetics of Ticlopidine

    • Philip Teitelbaum
    Pages 27-40

  5. Ticlopidine’s Mechanism of Action on Human Platelets

    • Laurence A. Harker, John J. Bruno
    Pages 41-59

  6. Clinical Studies of Stroke Prevention with Ticlopidine in Man

    • William Pryse-Phillips
    Pages 61-74

  7. Clinical Trials of Ticlopidine in Patients with Intermittent Claudication

    • Lars Janzon
    Pages 75-84

  8. Clinical Trials of Ticlopidine in Patients with Coronary Artery Disease

    • Francesco Balsano, Francesco Violi
    Pages 85-98

  9. A Systematic Overview of Randomized Trials of Antiplatelet Agents for the Prevention of Stroke, Myocardial Infarction, and Vascular Death

    • Michael Gent
    Pages 99-116

  10. An Analysis of the Side Effects of Ticlopidine

    • Basil A. Molony
    Pages 117-139

  11. The Role of Ticlopidine in Prevention of Ischemic Stroke: A Benefit-Risk Assessment

    • J. Donald Easton
    Pages 141-155

  12. Back Matter

    Pages 157-162
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Keywords

About this book

Blood platelets lack a nucleus. As a result their life span is short and they cannot reproduce themselves. Platelets share these qualities with the red blood cell. Plate­ lets and red blood cells, nevertheless, serve vital roles in the body. One major function of the platelet is its capacity to aggregate and thereby initiate intravas­ cular coagulation which often underlies such major diseases as myocardial infarc­ tion, cerebral infarction, and pulmonary embolism. For this reason in recent years, medical attention has been directed to drugs that inhibit platelet aggregation. Aspirin was the first drug to be proven effective in this area. Since then other drugs that share aspirin's fundamental biochemical action, inhibition of platelet cyclooxygenase, have also been studied. Very recently, ticlopidine, the first of what promises to be a new class of drugs inhibiting platelet aggregation and coagulation via an entirely different biochemical mechanism, has been exten­ sively studied and clinically shown to be as effective or more effective than aspirin in the prevention of ischemic cardiovascular and cerebrovascular disease.

Editors and Affiliations

  • Department of Neurology, New York University School of Medicine, New York, USA

    William K. Hass

  • Department of Neurology, Brown University Medical Center, Providence, USA

    J. Donald Easton

Bibliographic Information

  • Book Title: Ticlopidine, Platelets and Vascular Disease

  • Editors: William K. Hass, J. Donald Easton

  • DOI: https://doi.org/10.1007/978-1-4613-8306-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1993

  • Hardcover ISBN: 978-0-387-94009-0Due: 23 June 1993

  • Softcover ISBN: 978-1-4613-8308-6Published: 08 November 2011

  • eBook ISBN: 978-1-4613-8306-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 162

  • Topics: Cardiology, Pharmacology/Toxicology

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