Overview
- Editors:
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Michael E. Maragoudakis
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University of Patras Medical School, Patras, Greece
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Table of contents (22 chapters)
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Heterogeneity of Endothelial Cells
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- Peter I. Lelkes, Vangelis G. Manolopoulos, Matthew Silverman, Shaosong Zhang, Soverin Karmiol, Brian R. Unsworth
Pages 1-17
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- D. S. Grant, J. L. Kinsella, H. K. Kleinman
Pages 19-29
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Role of Extracellular Matrix in Angiogenesis
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- Jing Han, Nicholas A. Kefalides
Pages 31-36
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- Victor W. M. van Hinsbergh, Pieter Koolwijk, Roeland Hanemaaijer
Pages 37-49
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- S. K. Williamson, R. W. Rose, M. O’Hara, D. S. Grant
Pages 51-60
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Angiogenic Factors and Their Receptors
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- Anna Gualandris, Marco Rusnati, Patrizia Dell’Era, Daniela Coltrini, Elena Tanghetti, Emanuele Nelli et al.
Pages 61-72
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- Eliot M. Rosen, Itzhak D. Goldberg
Pages 85-94
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- Luisa A. DiPietro, Peter J. Polverini
Pages 105-113
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Physiological Angiogenesis
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- Lawrence P. Reynolds, Dale A. Redmer, Anna T. Grazul-Bilska, S. Derek Killilea, R. M. Moor
Pages 125-139
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- O. Hudlicka, M. D. Brown, S. Egginton
Pages 141-150
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- James S. Constant, David Y. Suh, M. Zamirul Hussain, Thomas K. Hunt
Pages 151-159
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- W. Douglas Thompson, Stephen J. McNally, Naren Ganesalingam, Deirdre S. E. McCallion, Christina M. Stirk, William T. Melvin
Pages 161-172
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Pathological Angiogenesis
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- Michael Höckel, Karlheinz Schienger, Margarete Mitze
Pages 173-179
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- Eliot M. Rosen, Peter J. Polverini, Brian J. Nickoloff, Itzhak D. Goldberg
Pages 181-189
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- Timothy Hla, Ari Ristimäki, Kirsi Narko, Pazit Ben-Av, Menq-Jer Lee, Mark Evans et al.
Pages 191-198
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Inhibitors of Angiogenesis
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- Robert J. Tressler, J. Wee, N. Storm, P. Fugedi, C. Peto, R. J. Stack et al.
Pages 199-211
About this book
There has been an explosion of research activity related to angiogenesis in recent years, and hundreds of laboratories worldwide are actively involved in many aspects of angiogenesiS. The literature on angiogenesis increases exponentially every year, and more than 16,000 peer-reviewed articles have been published the past 25 years, which are scattered in basic science and clinical journals. The complexity of the cascade of events leading to new vessel formation from preexisting ones has challenged scientists in cell biology, biochemistry, physiology, pharmacology, molecular biology, developmental biology, and other fields. With their multidisciplinary approach and the powerful new techniques that have been developed, the progress in understanding angiogenesis has been impressive indeed. Only 12 years ago the mention of an angiogenic factor caused skepticism. Today we have the complete amino-acid fiequence and their genes cloned for at least 9 angiogenic factors. Many laboratories are studying their role in angiogenesis, and several biotechnology firms have a keen interest in commercial developments relative to these molecules. The role of extracellular matrix components in angiogenesis and the interaction of endothelial cells with other cell types such as pericytes, smooth muscle cells, and inflammatory cells have been studied by other groups. This rapid expansion is the result of a realization that in many disease states a common underlying pathology is a derangement in angiogenesis.
Editors and Affiliations
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University of Patras Medical School, Patras, Greece
Michael E. Maragoudakis